Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970249505> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2970249505 endingPage "954" @default.
- W2970249505 startingPage "947" @default.
- W2970249505 abstract "To analyze the intratumoral immunohistochemical expression of renin and its value as a prognostic factor for recurrence in nonmetastatic clear cell renal cell carcinoma (ccRCC). A total of 498 patients with nonmetastatic ccRCC from the Latin American Renal Cancer Group database who underwent partial or radical nephrectomy between 1990 and 2016 were selected. All cases were revised, and 2 distinct samples were obtained for tissue microarray construction. Ten years of follow-up was assessed, and disease-free survival rates (DFS) were analyzed. Renin expression was classified qualitatively as negative or positive. For the quantitative analysis, a cutoff was estimated using the maximum of the standardized log-rank statistic. Nuclear renin was qualitatively positive in 360 cases (72%) and negative in 138 (28%), whereas quantitatively, an equal number of cases had ≤35% or >35% renin-positive nuclei. The absence of renin expression was associated with high-grade tumors (by ISUP and Fuhrman classification, both P < 0.001), greater microscopic venous invasion (P = 0.046), and renal vein invasion (P = 0.026). In the multivariate analyses, qualitatively negative renin expression was an unfavorable prognostic factor for DFS (RR = 2.923, P < 0.001). With regard to quantitative renin expression, a cutoff of ≤35 was associated with worse DFS (RR = 4.085, P < 0.001). The intratumoral immunohistochemical expression of renin in patients with ccRCC provides valuable prognostic data regarding the likelihood of recurrence." @default.
- W2970249505 created "2019-09-05" @default.
- W2970249505 creator A5000078886 @default.
- W2970249505 creator A5006130921 @default.
- W2970249505 creator A5009349073 @default.
- W2970249505 creator A5013166621 @default.
- W2970249505 creator A5021145735 @default.
- W2970249505 creator A5048719369 @default.
- W2970249505 creator A5075799959 @default.
- W2970249505 creator A5076441878 @default.
- W2970249505 date "2019-12-01" @default.
- W2970249505 modified "2023-10-18" @default.
- W2970249505 title "Immunohistochemical expression of renin is a prognostic factor for recurrence in nonmetastatic renal cell carcinoma" @default.
- W2970249505 cites W1977247044 @default.
- W2970249505 cites W1984781901 @default.
- W2970249505 cites W2003723816 @default.
- W2970249505 cites W2021592757 @default.
- W2970249505 cites W2026707626 @default.
- W2970249505 cites W2038750132 @default.
- W2970249505 cites W2039545078 @default.
- W2970249505 cites W2054367364 @default.
- W2970249505 cites W2069480574 @default.
- W2970249505 cites W2070640824 @default.
- W2970249505 cites W2097096070 @default.
- W2970249505 cites W2103854447 @default.
- W2970249505 cites W2109735642 @default.
- W2970249505 cites W2141577422 @default.
- W2970249505 cites W2142274244 @default.
- W2970249505 cites W2164317031 @default.
- W2970249505 cites W2168133848 @default.
- W2970249505 cites W2171240286 @default.
- W2970249505 cites W2235523093 @default.
- W2970249505 cites W2284518822 @default.
- W2970249505 cites W2768723556 @default.
- W2970249505 cites W2789546037 @default.
- W2970249505 doi "https://doi.org/10.1016/j.urolonc.2019.07.012" @default.
- W2970249505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31473089" @default.
- W2970249505 hasPublicationYear "2019" @default.
- W2970249505 type Work @default.
- W2970249505 sameAs 2970249505 @default.
- W2970249505 citedByCount "2" @default.
- W2970249505 countsByYear W29702495052021 @default.
- W2970249505 countsByYear W29702495052023 @default.
- W2970249505 crossrefType "journal-article" @default.
- W2970249505 hasAuthorship W2970249505A5000078886 @default.
- W2970249505 hasAuthorship W2970249505A5006130921 @default.
- W2970249505 hasAuthorship W2970249505A5009349073 @default.
- W2970249505 hasAuthorship W2970249505A5013166621 @default.
- W2970249505 hasAuthorship W2970249505A5021145735 @default.
- W2970249505 hasAuthorship W2970249505A5048719369 @default.
- W2970249505 hasAuthorship W2970249505A5075799959 @default.
- W2970249505 hasAuthorship W2970249505A5076441878 @default.
- W2970249505 hasConcept C126322002 @default.
- W2970249505 hasConcept C126894567 @default.
- W2970249505 hasConcept C142724271 @default.
- W2970249505 hasConcept C143998085 @default.
- W2970249505 hasConcept C204232928 @default.
- W2970249505 hasConcept C2777472916 @default.
- W2970249505 hasConcept C2777546739 @default.
- W2970249505 hasConcept C2780091579 @default.
- W2970249505 hasConcept C2780227381 @default.
- W2970249505 hasConcept C2781278892 @default.
- W2970249505 hasConcept C71924100 @default.
- W2970249505 hasConceptScore W2970249505C126322002 @default.
- W2970249505 hasConceptScore W2970249505C126894567 @default.
- W2970249505 hasConceptScore W2970249505C142724271 @default.
- W2970249505 hasConceptScore W2970249505C143998085 @default.
- W2970249505 hasConceptScore W2970249505C204232928 @default.
- W2970249505 hasConceptScore W2970249505C2777472916 @default.
- W2970249505 hasConceptScore W2970249505C2777546739 @default.
- W2970249505 hasConceptScore W2970249505C2780091579 @default.
- W2970249505 hasConceptScore W2970249505C2780227381 @default.
- W2970249505 hasConceptScore W2970249505C2781278892 @default.
- W2970249505 hasConceptScore W2970249505C71924100 @default.
- W2970249505 hasIssue "12" @default.
- W2970249505 hasLocation W29702495051 @default.
- W2970249505 hasLocation W29702495052 @default.
- W2970249505 hasOpenAccess W2970249505 @default.
- W2970249505 hasPrimaryLocation W29702495051 @default.
- W2970249505 hasRelatedWork W1976968719 @default.
- W2970249505 hasRelatedWork W2017701036 @default.
- W2970249505 hasRelatedWork W2038759101 @default.
- W2970249505 hasRelatedWork W2045737731 @default.
- W2970249505 hasRelatedWork W2117195580 @default.
- W2970249505 hasRelatedWork W2353641271 @default.
- W2970249505 hasRelatedWork W2412410681 @default.
- W2970249505 hasRelatedWork W2443482734 @default.
- W2970249505 hasRelatedWork W2995427600 @default.
- W2970249505 hasRelatedWork W3157704015 @default.
- W2970249505 hasVolume "37" @default.
- W2970249505 isParatext "false" @default.
- W2970249505 isRetracted "false" @default.
- W2970249505 magId "2970249505" @default.
- W2970249505 workType "article" @default.