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- W2970256094 endingPage "100497" @default.
- W2970256094 startingPage "100497" @default.
- W2970256094 abstract "Abstract Since many decades, strains of Saccharomyces genus are being employed in several bioprocess set-ups for the production of bioethanol. Recently, osmo/halotolerant strains of Zygosaccharomyces has been identified and recognized as a potential model system for bioethanol production owing to the ability of the strains to withstand stringently harsh environment conditions, the same that yeasts face in any bioprocessing set-up. Zygosaccharomyces strains have been bestowed with a variety of industrially beneficial physiological traits that enable Zygosaccharomyces strains to withstand low pH, high osmolarity, high ethanol, high temperature and other conditions. Unlike Mendelian traits, these physiological capabilities are governed by multiple genes (polygenes) and are, therefore, regarded as polygenic or quantitative traits. The characterization of genes/loci associated with these traits is called as quantitative trait loci (QTL) mapping. To date, for improved bioethanol production, researchers have mainly used genetic/metabolic engineering, and media/process optimization strategies using mainly Saccharomyces as a model system. However, such strategies have only showed limited success. In this work, we wish to present methodological approach for generating F1, F2 and recombinant progeny population through genetic crossing of two divergent yeast strains in order to achieve descendants improved phenotypic robustness, improved adaptation to hostile bioprocess conditions (such as low pH, low nitrogen, high osmolarity, high ethanol, high temperature and high inhibitor concentration) and increase bioethanol production. So far as our knowledge is concerned, no one has ever applied this approach in India or globally for improving bioethanol production at large-scale. We believe that the presented methodological approach holds high promise for technology transfer, commercialization and also for meeting the future increasing demands of the biofuel/bioenergy in India." @default.
- W2970256094 created "2019-09-05" @default.
- W2970256094 creator A5020745219 @default.
- W2970256094 creator A5074609514 @default.
- W2970256094 date "2019-12-01" @default.
- W2970256094 modified "2023-09-26" @default.
- W2970256094 title "Current status of genetic & metabolic engineering and novel QTL mapping-based strategic approach in bioethanol production" @default.
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