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- W2970285412 abstract "Abstract Aggresomes are inclusion bodies for misfolded/aggregated proteins. Despite the role of misfolded/aggregated proteins in neurological disorders, their role in cancer pathogenesis is poorly defined. In the current study we aimed to investigate whether aggresomes-positivity could be used to improve the disease subclassification and prognosis prediction of pediatric medulloblastoma. Ninety three pediatric medulloblastoma tumor samples were retrospectively stratified into three molecular subgroups; WNT, SHH and non-WNT/non-SHH, using immunohistochemistry and Multiplex Ligation Probe Amplification. Formation of aggresomes were detected using immunohistochemistry. Overall survival (OS) and event-free survival (EFS) were determined according to risk stratification criteria. Multivariate Cox regression analyses were carried out to exclude confounders. Aggresomes formation was detected in 63.4% (n = 59/93) of samples. Aggresomes were non-randomly distributed among different molecular subgroups ( P = 0.00002). Multivariate Cox model identified aggresomes’ percentage at ≥20% to be significantly correlated with patient outcome in both OS (HR = 3.419; 95% CI, 1.30–8.93; P = 0.01) and EFS (HR = 3; 95% CI, 1.19–7.53; P = 0.02). The presence of aggresomes in ≥20% of the tumor identified poor responders in standard risk patients; OS ( P = 0.02) and EFS ( P = 0.06), and significantly correlated with poor outcome in non-WNT/non-SHH molecular subgroup; OS ( P = 0.0002) and EFS ( P = 0.0004)." @default.
- W2970285412 created "2019-09-05" @default.
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- W2970285412 date "2019-08-30" @default.
- W2970285412 modified "2023-10-14" @default.
- W2970285412 title "Association of Aggresomes with Survival Outcomes in Pediatric Medulloblastoma" @default.
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- W2970285412 doi "https://doi.org/10.1038/s41598-019-49027-x" @default.
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