Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970291663> ?p ?o ?g. }
- W2970291663 abstract "Abstract Although a wide variety of quantum computers are currently being developed, actual computational results have been largely restricted to contrived, artificial tasks. Finding ways to apply quantum computers to useful, real-world computational tasks remains an active research area. Here we describe our mapping of the protein design problem to the D-Wave quantum annealer. We present a system whereby Rosetta, a state-of-the-art protein design software suite, interfaces with the D-Wave quantum processing unit to find amino acid side chain identities and conformations to stabilize a fixed protein backbone. Our approach, which we call the QPacker , uses a large side-chain rotamer library and the full Rosetta energy function, and in no way reduces the design task to a simpler format. We demonstrate that quantum annealer-based design can be applied to complex real-world design tasks, producing designed molecules comparable to those produced by widely adopted classical design approaches. We also show through large-scale classical folding simulations that the results produced on the quantum annealer can inform wet-lab experiments. For design tasks that scale exponentially on classical computers, the QPacker achieves nearly constant runtime performance over the range of problem sizes that could be tested. We anticipate better than classical performance scaling as quantum computers mature." @default.
- W2970291663 created "2019-09-05" @default.
- W2970291663 creator A5001503348 @default.
- W2970291663 creator A5003557201 @default.
- W2970291663 creator A5005802927 @default.
- W2970291663 creator A5006974299 @default.
- W2970291663 creator A5025372662 @default.
- W2970291663 creator A5026484447 @default.
- W2970291663 creator A5055203249 @default.
- W2970291663 creator A5056012636 @default.
- W2970291663 creator A5068514328 @default.
- W2970291663 creator A5071639489 @default.
- W2970291663 date "2019-09-02" @default.
- W2970291663 modified "2023-09-27" @default.
- W2970291663 title "Designing Peptides on a Quantum Computer" @default.
- W2970291663 cites W1505986412 @default.
- W2970291663 cites W1969644422 @default.
- W2970291663 cites W1983624953 @default.
- W2970291663 cites W2001931036 @default.
- W2970291663 cites W2005169770 @default.
- W2970291663 cites W2008372467 @default.
- W2970291663 cites W2012206667 @default.
- W2970291663 cites W2015526636 @default.
- W2970291663 cites W2018111733 @default.
- W2970291663 cites W2043010716 @default.
- W2970291663 cites W2049275721 @default.
- W2970291663 cites W2066381187 @default.
- W2970291663 cites W2067905861 @default.
- W2970291663 cites W2070992435 @default.
- W2970291663 cites W2082351355 @default.
- W2970291663 cites W2084493621 @default.
- W2970291663 cites W2086361102 @default.
- W2970291663 cites W2107520340 @default.
- W2970291663 cites W2121627241 @default.
- W2970291663 cites W2132184418 @default.
- W2970291663 cites W2135815512 @default.
- W2970291663 cites W2141795045 @default.
- W2970291663 cites W2155333098 @default.
- W2970291663 cites W2172114588 @default.
- W2970291663 cites W2179731956 @default.
- W2970291663 cites W2201713963 @default.
- W2970291663 cites W2201936551 @default.
- W2970291663 cites W2330002776 @default.
- W2970291663 cites W2433987067 @default.
- W2970291663 cites W2520613901 @default.
- W2970291663 cites W2558615493 @default.
- W2970291663 cites W2606439133 @default.
- W2970291663 cites W2624703541 @default.
- W2970291663 cites W2754797405 @default.
- W2970291663 cites W2758259983 @default.
- W2970291663 cites W2763971786 @default.
- W2970291663 cites W2773080986 @default.
- W2970291663 cites W2781738013 @default.
- W2970291663 cites W2898987386 @default.
- W2970291663 cites W2904947448 @default.
- W2970291663 cites W2963418941 @default.
- W2970291663 cites W3101479050 @default.
- W2970291663 cites W941393951 @default.
- W2970291663 doi "https://doi.org/10.1101/752485" @default.
- W2970291663 hasPublicationYear "2019" @default.
- W2970291663 type Work @default.
- W2970291663 sameAs 2970291663 @default.
- W2970291663 citedByCount "28" @default.
- W2970291663 countsByYear W29702916632020 @default.
- W2970291663 countsByYear W29702916632021 @default.
- W2970291663 countsByYear W29702916632022 @default.
- W2970291663 countsByYear W29702916632023 @default.
- W2970291663 crossrefType "posted-content" @default.
- W2970291663 hasAuthorship W2970291663A5001503348 @default.
- W2970291663 hasAuthorship W2970291663A5003557201 @default.
- W2970291663 hasAuthorship W2970291663A5005802927 @default.
- W2970291663 hasAuthorship W2970291663A5006974299 @default.
- W2970291663 hasAuthorship W2970291663A5025372662 @default.
- W2970291663 hasAuthorship W2970291663A5026484447 @default.
- W2970291663 hasAuthorship W2970291663A5055203249 @default.
- W2970291663 hasAuthorship W2970291663A5056012636 @default.
- W2970291663 hasAuthorship W2970291663A5068514328 @default.
- W2970291663 hasAuthorship W2970291663A5071639489 @default.
- W2970291663 hasBestOaLocation W29702916631 @default.
- W2970291663 hasConcept C119599485 @default.
- W2970291663 hasConcept C121332964 @default.
- W2970291663 hasConcept C127413603 @default.
- W2970291663 hasConcept C159985019 @default.
- W2970291663 hasConcept C192562407 @default.
- W2970291663 hasConcept C199360897 @default.
- W2970291663 hasConcept C204323151 @default.
- W2970291663 hasConcept C2524010 @default.
- W2970291663 hasConcept C2776545253 @default.
- W2970291663 hasConcept C2777904410 @default.
- W2970291663 hasConcept C33923547 @default.
- W2970291663 hasConcept C41008148 @default.
- W2970291663 hasConcept C459310 @default.
- W2970291663 hasConcept C58053490 @default.
- W2970291663 hasConcept C62520636 @default.
- W2970291663 hasConcept C80444323 @default.
- W2970291663 hasConcept C84114770 @default.
- W2970291663 hasConcept C99844830 @default.
- W2970291663 hasConceptScore W2970291663C119599485 @default.
- W2970291663 hasConceptScore W2970291663C121332964 @default.
- W2970291663 hasConceptScore W2970291663C127413603 @default.