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- W2970292809 abstract "A one-pot and modular approach to the synthesis of 2,4(5)-disubstituted imidazoles was developed based on ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes. This methodology afforded twenty-nine disubstituted NH-imidazoles (23%–85% yield). A three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation–condensation protocol, followed by bromination and Suzuki coupling in the imidazole ring to yield trisubstituted NH-imidazoles (23%–69%, three steps). This approach was also employed in the synthesis of known inhibitor GSK3037619A." @default.
- W2970292809 created "2019-09-05" @default.
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- W2970292809 date "2019-08-28" @default.
- W2970292809 modified "2023-10-17" @default.
- W2970292809 title "Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors" @default.
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- W2970292809 doi "https://doi.org/10.1021/acs.joc.9b01844" @default.
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