Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970295815> ?p ?o ?g. }
- W2970295815 endingPage "675.e2" @default.
- W2970295815 startingPage "666" @default.
- W2970295815 abstract "Distant metastases are responsible for the majority of melanoma mortalities. As a critical barrier against metastasis, anoikis is a distinct programmed cell death induced by the integrated stress from extracellular matrix (ECM) detachment. In order to survive, tumor cells employ various strategies for overcoming this barrier. Recently, Sesn2 has been reported to play a protective role against integrated stress. In this study, we found that ECM detachment triggered the upregulation of Sesn2 in metastatic melanoma cells. The knockdown of Sesn2 impaired not only the cell viability but also the tumor sphere formation of melanoma cells in suspension cultures. Moreover, an elevated oxidative stress level was detected in Sesn2-silencing melanoma cells in suspension cultures, accompanied with an increased apoptosis rate. Finally, in vivo studies indicated that the Sesn2-knockdown reduced the formation of distant metastasis remarkably. Taken together, our findings illustrated that the upregulation of Sesn2 in response to suspension stress plays a protective role in melanoma against anoikis by detoxifying oxidative stress. Distant metastases are responsible for the majority of melanoma mortalities. As a critical barrier against metastasis, anoikis is a distinct programmed cell death induced by the integrated stress from extracellular matrix (ECM) detachment. In order to survive, tumor cells employ various strategies for overcoming this barrier. Recently, Sesn2 has been reported to play a protective role against integrated stress. In this study, we found that ECM detachment triggered the upregulation of Sesn2 in metastatic melanoma cells. The knockdown of Sesn2 impaired not only the cell viability but also the tumor sphere formation of melanoma cells in suspension cultures. Moreover, an elevated oxidative stress level was detected in Sesn2-silencing melanoma cells in suspension cultures, accompanied with an increased apoptosis rate. Finally, in vivo studies indicated that the Sesn2-knockdown reduced the formation of distant metastasis remarkably. Taken together, our findings illustrated that the upregulation of Sesn2 in response to suspension stress plays a protective role in melanoma against anoikis by detoxifying oxidative stress." @default.
- W2970295815 created "2019-09-05" @default.
- W2970295815 creator A5000110317 @default.
- W2970295815 creator A5008998082 @default.
- W2970295815 creator A5009573286 @default.
- W2970295815 creator A5023006263 @default.
- W2970295815 creator A5028458322 @default.
- W2970295815 creator A5047013876 @default.
- W2970295815 creator A5054850370 @default.
- W2970295815 creator A5059926395 @default.
- W2970295815 creator A5082691013 @default.
- W2970295815 creator A5084195289 @default.
- W2970295815 date "2020-03-01" @default.
- W2970295815 modified "2023-10-17" @default.
- W2970295815 title "Metastatic Melanoma Cells Rely on Sestrin2 to Acquire Anoikis Resistance via Detoxifying Intracellular ROS" @default.
- W2970295815 cites W1531386034 @default.
- W2970295815 cites W1550713401 @default.
- W2970295815 cites W1949238489 @default.
- W2970295815 cites W1969909442 @default.
- W2970295815 cites W1973871728 @default.
- W2970295815 cites W1998707180 @default.
- W2970295815 cites W2012015257 @default.
- W2970295815 cites W2012783067 @default.
- W2970295815 cites W2023465240 @default.
- W2970295815 cites W2026044755 @default.
- W2970295815 cites W2039403501 @default.
- W2970295815 cites W2055500932 @default.
- W2970295815 cites W2067829376 @default.
- W2970295815 cites W2075956249 @default.
- W2970295815 cites W2087614405 @default.
- W2970295815 cites W2090023298 @default.
- W2970295815 cites W2100628426 @default.
- W2970295815 cites W2142141154 @default.
- W2970295815 cites W2144884298 @default.
- W2970295815 cites W2147785354 @default.
- W2970295815 cites W2152606604 @default.
- W2970295815 cites W2178696016 @default.
- W2970295815 cites W2264038168 @default.
- W2970295815 cites W2278990798 @default.
- W2970295815 cites W2325422538 @default.
- W2970295815 cites W2341044585 @default.
- W2970295815 cites W2415290666 @default.
- W2970295815 cites W2557222435 @default.
- W2970295815 cites W2586407709 @default.
- W2970295815 cites W2606686841 @default.
- W2970295815 cites W2621333085 @default.
- W2970295815 cites W2622950952 @default.
- W2970295815 cites W2626666302 @default.
- W2970295815 cites W2739470863 @default.
- W2970295815 cites W2741577505 @default.
- W2970295815 cites W2751104580 @default.
- W2970295815 cites W2783572892 @default.
- W2970295815 cites W2790429725 @default.
- W2970295815 cites W2790757017 @default.
- W2970295815 cites W2800247717 @default.
- W2970295815 cites W2890738628 @default.
- W2970295815 cites W2901840140 @default.
- W2970295815 cites W4211123988 @default.
- W2970295815 doi "https://doi.org/10.1016/j.jid.2019.07.720" @default.
- W2970295815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31476315" @default.
- W2970295815 hasPublicationYear "2020" @default.
- W2970295815 type Work @default.
- W2970295815 sameAs 2970295815 @default.
- W2970295815 citedByCount "16" @default.
- W2970295815 countsByYear W29702958152020 @default.
- W2970295815 countsByYear W29702958152021 @default.
- W2970295815 countsByYear W29702958152022 @default.
- W2970295815 countsByYear W29702958152023 @default.
- W2970295815 crossrefType "journal-article" @default.
- W2970295815 hasAuthorship W2970295815A5000110317 @default.
- W2970295815 hasAuthorship W2970295815A5008998082 @default.
- W2970295815 hasAuthorship W2970295815A5009573286 @default.
- W2970295815 hasAuthorship W2970295815A5023006263 @default.
- W2970295815 hasAuthorship W2970295815A5028458322 @default.
- W2970295815 hasAuthorship W2970295815A5047013876 @default.
- W2970295815 hasAuthorship W2970295815A5054850370 @default.
- W2970295815 hasAuthorship W2970295815A5059926395 @default.
- W2970295815 hasAuthorship W2970295815A5082691013 @default.
- W2970295815 hasAuthorship W2970295815A5084195289 @default.
- W2970295815 hasBestOaLocation W29702958151 @default.
- W2970295815 hasConcept C104317684 @default.
- W2970295815 hasConcept C127561419 @default.
- W2970295815 hasConcept C152000582 @default.
- W2970295815 hasConcept C173396325 @default.
- W2970295815 hasConcept C185592680 @default.
- W2970295815 hasConcept C189165786 @default.
- W2970295815 hasConcept C190283241 @default.
- W2970295815 hasConcept C2777658100 @default.
- W2970295815 hasConcept C31573885 @default.
- W2970295815 hasConcept C502942594 @default.
- W2970295815 hasConcept C53227056 @default.
- W2970295815 hasConcept C55493867 @default.
- W2970295815 hasConcept C86803240 @default.
- W2970295815 hasConcept C95444343 @default.
- W2970295815 hasConceptScore W2970295815C104317684 @default.
- W2970295815 hasConceptScore W2970295815C127561419 @default.
- W2970295815 hasConceptScore W2970295815C152000582 @default.
- W2970295815 hasConceptScore W2970295815C173396325 @default.