FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970364555> ?p ?o ?g. }

• W2970364555 endingPage "650" @default.
• W2970364555 startingPage "642" @default.
• W2970364555 abstract "Abstract miR‐125a is a microRNA that is frequently diminished in various human malignancies. However, the mechanism by which impaired miR‐125a promotes cancer growth remains undefined. In this study, we investigated the role of miR‐125a in the proliferation and apoptosis of multiple myeloma (MM). To do this, we used MM tissue samples (from 40 anonymous patients), normal matched control samples, and five MM‐derived cell lines. We also established a mouse model of MM xenograft to explore the effect of overexpression of miR‐125a on the MM growth in vivo. Quantitative real‐time polymerase chain reaction revealed that the miR‐125a expression was broadly reduced in MM tissues and cell lines. The impairment of miR‐125a in MM tissues was functionally relevant because the overexpression of miR‐125a remarkably decreased the cell viability and colony‐forming activity, at least in part, by promoting apoptosis in two miR‐125a‐deficient MM cell lines: NCI‐H929 and U266. Interestingly, we also discovered that the human gene encoding the ubiquitin‐specific peptidase 5 (USP5), which is known to promote cellular deubiquitination and ubiquitin/proteasome‐dependent proteolysis, was a direct transcriptional target for miR‐125a to repress. More importantly, the heterologous expression of USP5 significantly reversed the growth‐inhibitory effects of miR‐125a on MM cells in vitro. In the mouse xenograft model, overexpressed miR‐125a prominently inhibited the growth of MM tumors and concomitantly reduced the expression of USP5 in tumor tissues. These results suggest that miR‐125a inhibits the expression of USP5, thereby mitigating the proliferation and survival of malignant MM cells. We propose that USP5 acts as an oncoprotein in miR‐125a‐missing cancers." @default.
• W2970364555 created "2019-09-05" @default.
• W2970364555 creator A5003062979 @default.
• W2970364555 creator A5003293441 @default.
• W2970364555 creator A5012718640 @default.
• W2970364555 creator A5031188584 @default.
• W2970364555 creator A5059043045 @default.
• W2970364555 creator A5068817808 @default.
• W2970364555 creator A5090735554 @default.
• W2970364555 creator A5071434013 @default.
• W2970364555 date "2019-08-26" @default.
• W2970364555 modified "2023-09-23" @default.
• W2970364555 title "miR‐125a suppresses malignancy of multiple myeloma by reducing the deubiquitinase USP5" @default.
• W2970364555 cites W1832030339 @default.
• W2970364555 cites W1887207058 @default.
• W2970364555 cites W1964502574 @default.
• W2970364555 cites W1969188594 @default.
• W2970364555 cites W1970860552 @default.
• W2970364555 cites W1989259853 @default.
• W2970364555 cites W1998651094 @default.
• W2970364555 cites W2004902039 @default.
• W2970364555 cites W2042748226 @default.
• W2970364555 cites W2050039220 @default.
• W2970364555 cites W2050496379 @default.
• W2970364555 cites W2053508383 @default.
• W2970364555 cites W2054666944 @default.
• W2970364555 cites W2083409948 @default.
• W2970364555 cites W2089658797 @default.
• W2970364555 cites W2102381062 @default.
• W2970364555 cites W2107290223 @default.
• W2970364555 cites W2109200119 @default.
• W2970364555 cites W2114047398 @default.
• W2970364555 cites W2152705760 @default.
• W2970364555 cites W2171641698 @default.
• W2970364555 cites W2175928272 @default.
• W2970364555 cites W2211665239 @default.
• W2970364555 cites W2252647763 @default.
• W2970364555 cites W2264436887 @default.
• W2970364555 cites W2319950821 @default.
• W2970364555 cites W2464970426 @default.
• W2970364555 cites W2527599582 @default.
• W2970364555 cites W2556354844 @default.
• W2970364555 cites W2588025094 @default.
• W2970364555 cites W2603228434 @default.
• W2970364555 cites W2604377167 @default.
• W2970364555 cites W2605346368 @default.
• W2970364555 cites W2610026002 @default.
• W2970364555 cites W2616072553 @default.
• W2970364555 cites W2626414898 @default.
• W2970364555 cites W2748200846 @default.
• W2970364555 cites W2756640516 @default.
• W2970364555 cites W2766193356 @default.
• W2970364555 cites W2810543935 @default.
• W2970364555 cites W2883580550 @default.
• W2970364555 cites W4211058750 @default.
• W2970364555 cites W4240931936 @default.
• W2970364555 doi "https://doi.org/10.1002/jcb.29309" @default.
• W2970364555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31452281" @default.
• W2970364555 hasPublicationYear "2019" @default.
• W2970364555 type Work @default.
• W2970364555 sameAs 2970364555 @default.
• W2970364555 citedByCount "16" @default.
• W2970364555 countsByYear W29703645552020 @default.
• W2970364555 countsByYear W29703645552021 @default.
• W2970364555 countsByYear W29703645552022 @default.
• W2970364555 countsByYear W29703645552023 @default.
• W2970364555 crossrefType "journal-article" @default.
• W2970364555 hasAuthorship W2970364555A5003062979 @default.
• W2970364555 hasAuthorship W2970364555A5003293441 @default.
• W2970364555 hasAuthorship W2970364555A5012718640 @default.
• W2970364555 hasAuthorship W2970364555A5031188584 @default.
• W2970364555 hasAuthorship W2970364555A5059043045 @default.
• W2970364555 hasAuthorship W2970364555A5068817808 @default.
• W2970364555 hasAuthorship W2970364555A5071434013 @default.
• W2970364555 hasAuthorship W2970364555A5090735554 @default.
• W2970364555 hasBestOaLocation W29703645551 @default.
• W2970364555 hasConcept C102658986 @default.
• W2970364555 hasConcept C104317684 @default.
• W2970364555 hasConcept C121608353 @default.
• W2970364555 hasConcept C145059251 @default.
• W2970364555 hasConcept C153911025 @default.
• W2970364555 hasConcept C173396325 @default.
• W2970364555 hasConcept C190283241 @default.
• W2970364555 hasConcept C25602115 @default.
• W2970364555 hasConcept C27740335 @default.
• W2970364555 hasConcept C502942594 @default.
• W2970364555 hasConcept C53227056 @default.
• W2970364555 hasConcept C54355233 @default.
• W2970364555 hasConcept C555283112 @default.
• W2970364555 hasConcept C62112901 @default.
• W2970364555 hasConcept C81885089 @default.
• W2970364555 hasConcept C86803240 @default.
• W2970364555 hasConcept C95444343 @default.
• W2970364555 hasConceptScore W2970364555C102658986 @default.
• W2970364555 hasConceptScore W2970364555C104317684 @default.
• W2970364555 hasConceptScore W2970364555C121608353 @default.
• W2970364555 hasConceptScore W2970364555C145059251 @default.
• W2970364555 hasConceptScore W2970364555C153911025 @default.

• next