FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970415110> ?p ?o ?g. }

• W2970415110 endingPage "e0221777" @default.
• W2970415110 startingPage "e0221777" @default.
• W2970415110 abstract "Inhaled nitric oxide (NO) exerts a variety of effects through metabolites and these play an important role in regulation of hemodynamics in the body. A detailed investigation into the generation of these metabolites has been overlooked.We investigated the kinetics of nitrite and S-nitrosothiol-hemoglobin (SNO-Hb) in plasma derived from inhaled NO subjects and how this modifies the cutaneous microvascular response.We enrolled 15 healthy volunteers. Plasma nitrite levels at baseline and during NO inhalation (15 minutes at 40 ppm) were 102 (86-118) and 114 (87-129) nM, respectively. The nitrite peak occurred at 5 minutes of discontinuing NO (131 (104-170) nM). Plasma nitrate levels were not significantly different during the study. SNO-Hb molar ratio levels at baseline and during NO inhalation were 4.7E-3 (2.5E-3-5.8E-3) and 7.8E-3 (4.1E-3-13.0E-3), respectively. Levels of SNO-Hb continued to climb up to the last study time point (30 min: 10.6E-3 (5.3E-3-15.5E-3)). The response to acetylcholine iontophoresis both before and during NO inhalation was inversely associated with the SNO-Hb level (r: -0.57, p = 0.03, and r: -0.54, p = 0.04, respectively).Both nitrite and SNO-Hb increase during NO inhalation. Nitrite increases first, followed by a more sustained increase in Hb-SNO. Nitrite and Hb-SNO could be a mobile reservoir of NO with potential implications on the systemic microvasculature." @default.
• W2970415110 created "2019-09-05" @default.
• W2970415110 creator A5007835171 @default.
• W2970415110 creator A5013457608 @default.
• W2970415110 creator A5022283496 @default.
• W2970415110 creator A5024244993 @default.
• W2970415110 creator A5027390072 @default.
• W2970415110 creator A5043629634 @default.
• W2970415110 creator A5065906558 @default.
• W2970415110 creator A5067568367 @default.
• W2970415110 creator A5071602867 @default.
• W2970415110 creator A5075159332 @default.
• W2970415110 creator A5083447104 @default.
• W2970415110 date "2019-08-30" @default.
• W2970415110 modified "2023-10-14" @default.
• W2970415110 title "A pilot study on the kinetics of metabolites and microvascular cutaneous effects of nitric oxide inhalation in healthy volunteers" @default.
• W2970415110 cites W1482038130 @default.
• W2970415110 cites W1603636964 @default.
• W2970415110 cites W1825248926 @default.
• W2970415110 cites W1828441724 @default.
• W2970415110 cites W1834041853 @default.
• W2970415110 cites W1845351874 @default.
• W2970415110 cites W1927797304 @default.
• W2970415110 cites W1965380611 @default.
• W2970415110 cites W1966448013 @default.
• W2970415110 cites W1969663514 @default.
• W2970415110 cites W1979230311 @default.
• W2970415110 cites W1980292532 @default.
• W2970415110 cites W1981716766 @default.
• W2970415110 cites W1984776459 @default.
• W2970415110 cites W1984997174 @default.
• W2970415110 cites W1986005376 @default.
• W2970415110 cites W1986079719 @default.
• W2970415110 cites W1994991333 @default.
• W2970415110 cites W1997578701 @default.
• W2970415110 cites W1999575173 @default.
• W2970415110 cites W2000887563 @default.
• W2970415110 cites W2004486757 @default.
• W2970415110 cites W2006977402 @default.
• W2970415110 cites W2007737411 @default.
• W2970415110 cites W2009383132 @default.
• W2970415110 cites W2010783235 @default.
• W2970415110 cites W2015642857 @default.
• W2970415110 cites W2016928245 @default.
• W2970415110 cites W2021707617 @default.
• W2970415110 cites W2024417244 @default.
• W2970415110 cites W2026144690 @default.
• W2970415110 cites W2027274832 @default.
• W2970415110 cites W2030864821 @default.
• W2970415110 cites W2035777067 @default.
• W2970415110 cites W2047428299 @default.
• W2970415110 cites W2051857669 @default.
• W2970415110 cites W2052458792 @default.
• W2970415110 cites W2054683833 @default.
• W2970415110 cites W2055935493 @default.
• W2970415110 cites W2056107685 @default.
• W2970415110 cites W2061078634 @default.
• W2970415110 cites W2067780389 @default.
• W2970415110 cites W2069763277 @default.
• W2970415110 cites W2073656165 @default.
• W2970415110 cites W2085680046 @default.
• W2970415110 cites W2092145002 @default.
• W2970415110 cites W2093223545 @default.
• W2970415110 cites W2094226736 @default.
• W2970415110 cites W2094746732 @default.
• W2970415110 cites W2095115132 @default.
• W2970415110 cites W2096257801 @default.
• W2970415110 cites W2102006737 @default.
• W2970415110 cites W2107111331 @default.
• W2970415110 cites W2107946046 @default.
• W2970415110 cites W2108104014 @default.
• W2970415110 cites W2108230662 @default.
• W2970415110 cites W2111609140 @default.
• W2970415110 cites W2112453730 @default.
• W2970415110 cites W2116023205 @default.
• W2970415110 cites W2117676608 @default.
• W2970415110 cites W2118726397 @default.
• W2970415110 cites W2122482827 @default.
• W2970415110 cites W2124270277 @default.
• W2970415110 cites W2128139551 @default.
• W2970415110 cites W2130449101 @default.
• W2970415110 cites W2140036859 @default.
• W2970415110 cites W2143120699 @default.
• W2970415110 cites W2145710767 @default.
• W2970415110 cites W2161221991 @default.
• W2970415110 cites W2163889067 @default.
• W2970415110 cites W2167191108 @default.
• W2970415110 cites W2169182236 @default.
• W2970415110 cites W2214794460 @default.
• W2970415110 cites W2217122755 @default.
• W2970415110 cites W227564737 @default.
• W2970415110 cites W2313326603 @default.
• W2970415110 cites W2324162185 @default.
• W2970415110 cites W2472343078 @default.
• W2970415110 cites W2558599725 @default.
• W2970415110 cites W2753340618 @default.
• W2970415110 cites W276682528 @default.
• W2970415110 cites W2783955363 @default.

• next