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- W2970415532 abstract "Chia seeds are a rich source of alpha-linolenic acid (ALA), but the acute plasma ALA response to chia seed or chia seed oil ingestion has not yet been determined. Female subjects (N=16, 20 to 45 y) reported to the lab after an overnight fast on 3 separate occasions and ingested, in random order by visit, a snack cluster (PL), snack cluster with 8 g milled chia seed (CS; 1.3 mg ALA), or chia seed oil (CSO; 1.3 mg ALA). A catheter was placed in an antecubital vein, and blood samples were taken at pre-ingestion and postingestion (0.5, 1.5, 2.5, 3.5, 4.5, and 6 h) during which the subjects rested and ingested a 550 kcal breakfast at post-1.75 h. Subjects returned to the lab to provide a 24 h sample. Blood samples were analyzed for ALA, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) using GC-MS. A 3 × 8 repeated measures ANOVA revealed a significant interaction effect for ALA (P<0.001) but not for EPA (P=0.581) or DHA (P=0.445). ALA in CS (↑82%) and CSO (↑91%) increased significantly 2.5 h post-ingestion and stayed elevated above PL with some attenuation at 3.5 h, dropping to pre-ingestion levels at 24 h. In conclusion, these bioavailability data indicate that 1.3 mg ALA from CS or CSO nearly doubles plasma ALA levels within 2.5 h ingestion, staying elevated for several hours, and then falling to pre-ingestion levels without conversion to EPA or DHA within 24 h. Funded by Dole Food Company, Inc." @default.
- W2970415532 created "2019-09-05" @default.
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- W2970415532 date "2013-04-01" @default.
- W2970415532 modified "2023-09-27" @default.
- W2970415532 title "Fatty acid bioavailability study of single oral doses of milled chia seed snack clusters or chia seed oil in healthy subjects" @default.
- W2970415532 doi "https://doi.org/10.1096/fasebj.27.1_supplement.125.5" @default.
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