FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970448198> ?p ?o ?g. }

• W2970448198 abstract "Abstract Aims To investigate the genetic factors contributing to early‐onset type 2 diabetes (EOD) in the Chinese Hans populations. Materials and methods For 2734 newly diagnosed type 2 diabetes patients and 4041 normal glycemic controls, 25 single nucleotide polymorphisms from 24 genomic loci linked to diabetes were successfully genotyped. Three genetic risk scores (GRSs) were constructed, including the weighted type 2 diabetes‐related GRS (wT‐GRS), the weighted β‐cell function‐related GRS (wB‐GRS), and the weighted GRS constructed by risk alleles not related to β‐cell function (wNB‐GRS). For patients with diabetes, EOD, middle‐age‐onset type 2 diabetes (MOD), and late‐onset type 2 diabetes (LOD) were defined by onset ages ≤40, 40 to 60, and ≥60 years, respectively. Results From single marker analysis, different gene profiles were identified between EOD and LOD patients. EOD patients had greater wT‐GRS and wB‐GRS values than LOD patients. After adjustment for sex, elevated wT‐GRS and wB‐GRS values were significantly associated with an increased risk for EOD by 1.11‐ and 1.21‐fold per allele ( P = 1.69 × 10 −7 ; 6.07 × 10 −8 ). The wT‐GRS and wNB‐GRS were nominally related to an increased risk of LOD by 1.03‐fold per allele ( P = 1.03 × 10 −2 , 1.78 × 10 −2 ). In patients with diabetes, higher wT‐GRS and wB‐GRS were associated with younger onset age [wT‐GRS: β (SE) = –0.0033(0.0016), P = 3.74 × 10 −2 ; wB‐GRS: −0.0076(0.0028), 7.45 × 10 −3 ] and decreased insulinogenic index [wT‐GRS: –0.0384(0.0098), 9.39 × 10 −5 ; wB‐GRS: −0.0722(0.0176), 4.21 × 10 −5 ]. Conclusion Our findings indicate a strong genetic predisposition for EOD, which can be mainly attributed to genetic variants linked to β‐cell function, suggesting the β‐cell dysfunction plays a key role in the pathogenesis of EOD in Chinese Han individuals." @default.
• W2970448198 created "2019-09-05" @default.
• W2970448198 creator A5038327368 @default.
• W2970448198 creator A5074066583 @default.
• W2970448198 creator A5079357621 @default.
• W2970448198 creator A5080819169 @default.
• W2970448198 creator A5088869525 @default.
• W2970448198 date "2019-09-10" @default.
• W2970448198 modified "2023-10-02" @default.
• W2970448198 title "Early‐onset type 2 diabetes is associated with genetic variants of β‐cell function in the Chinese Han population" @default.
• W2970448198 cites W1567871412 @default.
• W2970448198 cites W1721336579 @default.
• W2970448198 cites W1935567550 @default.
• W2970448198 cites W1966254895 @default.
• W2970448198 cites W1988465253 @default.
• W2970448198 cites W1997615325 @default.
• W2970448198 cites W2018863236 @default.
• W2970448198 cites W2020384330 @default.
• W2970448198 cites W2025665777 @default.
• W2970448198 cites W2031582662 @default.
• W2970448198 cites W2045559539 @default.
• W2970448198 cites W2053369310 @default.
• W2970448198 cites W2056526409 @default.
• W2970448198 cites W2073211589 @default.
• W2970448198 cites W2073757723 @default.
• W2970448198 cites W2085328577 @default.
• W2970448198 cites W2098558143 @default.
• W2970448198 cites W2103120998 @default.
• W2970448198 cites W2104875841 @default.
• W2970448198 cites W2106305501 @default.
• W2970448198 cites W2122895430 @default.
• W2970448198 cites W2130266732 @default.
• W2970448198 cites W2133795831 @default.
• W2970448198 cites W2135984480 @default.
• W2970448198 cites W2143260359 @default.
• W2970448198 cites W2147391073 @default.
• W2970448198 cites W2160234571 @default.
• W2970448198 cites W2167048252 @default.
• W2970448198 cites W2216924858 @default.
• W2970448198 cites W2345996780 @default.
• W2970448198 cites W2394936395 @default.
• W2970448198 cites W2605748423 @default.
• W2970448198 cites W2731349674 @default.
• W2970448198 cites W2791257111 @default.
• W2970448198 cites W2794189649 @default.
• W2970448198 cites W2833156267 @default.
• W2970448198 cites W2900407578 @default.
• W2970448198 cites W2922325669 @default.
• W2970448198 cites W4235902887 @default.
• W2970448198 doi "https://doi.org/10.1002/dmrr.3214" @default.
• W2970448198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31465628" @default.
• W2970448198 hasPublicationYear "2019" @default.
• W2970448198 type Work @default.
• W2970448198 sameAs 2970448198 @default.
• W2970448198 citedByCount "11" @default.
• W2970448198 countsByYear W29704481982019 @default.
• W2970448198 countsByYear W29704481982020 @default.
• W2970448198 countsByYear W29704481982021 @default.
• W2970448198 countsByYear W29704481982022 @default.
• W2970448198 countsByYear W29704481982023 @default.
• W2970448198 crossrefType "journal-article" @default.
• W2970448198 hasAuthorship W2970448198A5038327368 @default.
• W2970448198 hasAuthorship W2970448198A5074066583 @default.
• W2970448198 hasAuthorship W2970448198A5079357621 @default.
• W2970448198 hasAuthorship W2970448198A5080819169 @default.
• W2970448198 hasAuthorship W2970448198A5088869525 @default.
• W2970448198 hasConcept C104317684 @default.
• W2970448198 hasConcept C126322002 @default.
• W2970448198 hasConcept C134018914 @default.
• W2970448198 hasConcept C135763542 @default.
• W2970448198 hasConcept C153209595 @default.
• W2970448198 hasConcept C180754005 @default.
• W2970448198 hasConcept C2777180221 @default.
• W2970448198 hasConcept C2780473172 @default.
• W2970448198 hasConcept C2908647359 @default.
• W2970448198 hasConcept C2910068830 @default.
• W2970448198 hasConcept C54355233 @default.
• W2970448198 hasConcept C555293320 @default.
• W2970448198 hasConcept C71924100 @default.
• W2970448198 hasConcept C86803240 @default.
• W2970448198 hasConcept C90924648 @default.
• W2970448198 hasConcept C99454951 @default.
• W2970448198 hasConceptScore W2970448198C104317684 @default.
• W2970448198 hasConceptScore W2970448198C126322002 @default.
• W2970448198 hasConceptScore W2970448198C134018914 @default.
• W2970448198 hasConceptScore W2970448198C135763542 @default.
• W2970448198 hasConceptScore W2970448198C153209595 @default.
• W2970448198 hasConceptScore W2970448198C180754005 @default.
• W2970448198 hasConceptScore W2970448198C2777180221 @default.
• W2970448198 hasConceptScore W2970448198C2780473172 @default.
• W2970448198 hasConceptScore W2970448198C2908647359 @default.
• W2970448198 hasConceptScore W2970448198C2910068830 @default.
• W2970448198 hasConceptScore W2970448198C54355233 @default.
• W2970448198 hasConceptScore W2970448198C555293320 @default.
• W2970448198 hasConceptScore W2970448198C71924100 @default.
• W2970448198 hasConceptScore W2970448198C86803240 @default.
• W2970448198 hasConceptScore W2970448198C90924648 @default.
• W2970448198 hasConceptScore W2970448198C99454951 @default.
• W2970448198 hasFunder F4320321540 @default.
• W2970448198 hasIssue "2" @default.

• next