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- W2970449368 abstract "Objective: Asthma is correlated with a higher risk of manifesting other diseases, including hypertension, diabetes, obesity, psychiatric and neurological diseases, and cancer. Therefore, revealing this interplay between asthma and these illnesses may provide novel insights into their pathogenesis. Results: It is highly debated that dysregulation of Ca2+ homeostasis is involved in the pathogenesis of these maladies. Not surprisingly, calcium (Ca2+) channel blockers (CCBs), classically used as antihypertensive medicines, have been demonstrating off-label effects such as alleviating asthma symptoms, in addition to antidiabetic, antiobesity, anticancer and antineurodegenerative effects. Our studies about Ca2+/cAMP signalling may shed some new light on this field. Conclusion: Thus, considering that asthma and associated illnesses such as hypertension, diabetes, obesity, cancer and neurodegenerative diseases have become highly prevalent medical problems in the world, the comprehension of this interplay between asthma and other disorders could improve drug therapy." @default.
- W2970449368 created "2019-09-05" @default.
- W2970449368 creator A5044267709 @default.
- W2970449368 date "2020-03-24" @default.
- W2970449368 modified "2023-10-14" @default.
- W2970449368 title "The Interplay Between Asthma and Other Diseases: Role of Ca2+/cAMP Signalling" @default.
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- W2970449368 doi "https://doi.org/10.2174/1871530319666190828145854" @default.
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