Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970462984> ?p ?o ?g. }
- W2970462984 endingPage "2459" @default.
- W2970462984 startingPage "2441" @default.
- W2970462984 abstract "Aim: Alterations of microglia, the brain-resident macrophages, are associated with numerous brain pathologies. Genetic manipulation of microglia in diseases using small interfering RNA (siRNA) is hampered by the lack of safe and efficient siRNA delivery methods. We assessed the amphiphilic dendrimer (AD) for functional siRNA delivery and gene knockdown in primary microglia. Materials & methods: We characterized the ability of AD to form nanoparticles with siRNA, and studied their size, surface potential, cell uptake and gene silencing in rodent microglia. Results: AD effectively delivered siRNA to primary microglia and decreased target gene and protein expression, leading to transcriptomic changes without affecting basal microglial functions. Conclusion: The dendrimer AD promises to be an innocuous carrier for siRNA delivery into microglia." @default.
- W2970462984 created "2019-09-05" @default.
- W2970462984 creator A5002659900 @default.
- W2970462984 creator A5013925417 @default.
- W2970462984 creator A5017154115 @default.
- W2970462984 creator A5017814395 @default.
- W2970462984 creator A5019429747 @default.
- W2970462984 creator A5037395594 @default.
- W2970462984 creator A5039536580 @default.
- W2970462984 creator A5050446496 @default.
- W2970462984 creator A5060965882 @default.
- W2970462984 creator A5071859035 @default.
- W2970462984 creator A5077241499 @default.
- W2970462984 creator A5084724515 @default.
- W2970462984 date "2019-09-01" @default.
- W2970462984 modified "2023-10-18" @default.
- W2970462984 title "Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector" @default.
- W2970462984 cites W1438735567 @default.
- W2970462984 cites W1494319831 @default.
- W2970462984 cites W1921290898 @default.
- W2970462984 cites W1961550958 @default.
- W2970462984 cites W1963992284 @default.
- W2970462984 cites W1964146045 @default.
- W2970462984 cites W1994354502 @default.
- W2970462984 cites W1995770815 @default.
- W2970462984 cites W2008077459 @default.
- W2970462984 cites W2008134464 @default.
- W2970462984 cites W2018716983 @default.
- W2970462984 cites W2033105784 @default.
- W2970462984 cites W2033966441 @default.
- W2970462984 cites W2042602894 @default.
- W2970462984 cites W2050881037 @default.
- W2970462984 cites W2056959062 @default.
- W2970462984 cites W2058669152 @default.
- W2970462984 cites W2068335734 @default.
- W2970462984 cites W2074161384 @default.
- W2970462984 cites W2095194341 @default.
- W2970462984 cites W2117168077 @default.
- W2970462984 cites W2117786997 @default.
- W2970462984 cites W2118980569 @default.
- W2970462984 cites W2124836944 @default.
- W2970462984 cites W2131271579 @default.
- W2970462984 cites W2138207763 @default.
- W2970462984 cites W2161352835 @default.
- W2970462984 cites W2169456326 @default.
- W2970462984 cites W2171695814 @default.
- W2970462984 cites W2172326429 @default.
- W2970462984 cites W2192314619 @default.
- W2970462984 cites W2203955786 @default.
- W2970462984 cites W2220215167 @default.
- W2970462984 cites W2307310199 @default.
- W2970462984 cites W2322194451 @default.
- W2970462984 cites W2347178103 @default.
- W2970462984 cites W2414688524 @default.
- W2970462984 cites W2543601420 @default.
- W2970462984 cites W2594608863 @default.
- W2970462984 cites W2601705653 @default.
- W2970462984 cites W2617597517 @default.
- W2970462984 cites W2622807556 @default.
- W2970462984 cites W2769071992 @default.
- W2970462984 cites W2796983933 @default.
- W2970462984 cites W2802692244 @default.
- W2970462984 cites W2806121532 @default.
- W2970462984 cites W2887201177 @default.
- W2970462984 cites W2896833208 @default.
- W2970462984 cites W2898002732 @default.
- W2970462984 cites W2920438880 @default.
- W2970462984 cites W2945997494 @default.
- W2970462984 cites W4211039187 @default.
- W2970462984 doi "https://doi.org/10.2217/nnm-2019-0176" @default.
- W2970462984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31456476" @default.
- W2970462984 hasPublicationYear "2019" @default.
- W2970462984 type Work @default.
- W2970462984 sameAs 2970462984 @default.
- W2970462984 citedByCount "22" @default.
- W2970462984 countsByYear W29704629842020 @default.
- W2970462984 countsByYear W29704629842021 @default.
- W2970462984 countsByYear W29704629842022 @default.
- W2970462984 countsByYear W29704629842023 @default.
- W2970462984 crossrefType "journal-article" @default.
- W2970462984 hasAuthorship W2970462984A5002659900 @default.
- W2970462984 hasAuthorship W2970462984A5013925417 @default.
- W2970462984 hasAuthorship W2970462984A5017154115 @default.
- W2970462984 hasAuthorship W2970462984A5017814395 @default.
- W2970462984 hasAuthorship W2970462984A5019429747 @default.
- W2970462984 hasAuthorship W2970462984A5037395594 @default.
- W2970462984 hasAuthorship W2970462984A5039536580 @default.
- W2970462984 hasAuthorship W2970462984A5050446496 @default.
- W2970462984 hasAuthorship W2970462984A5060965882 @default.
- W2970462984 hasAuthorship W2970462984A5071859035 @default.
- W2970462984 hasAuthorship W2970462984A5077241499 @default.
- W2970462984 hasAuthorship W2970462984A5084724515 @default.
- W2970462984 hasBestOaLocation W29704629841 @default.
- W2970462984 hasConcept C104317684 @default.
- W2970462984 hasConcept C111599444 @default.
- W2970462984 hasConcept C119056186 @default.
- W2970462984 hasConcept C135983454 @default.
- W2970462984 hasConcept C166703698 @default.