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• W2970469141 abstract "Formation of the nervous system requires a complex series of events including proper extension and guidance of neuronal axons and dendrites. Here we investigate the requirement for integrins, a class of transmembrane cell adhesion receptors, in regulating these processes across classes of C. elegans motor neurons. We show α integrin/ina-1 is expressed by both GABAergic and cholinergic motor neurons. Despite this, our analysis of hypomorphic ina-1(gm144) mutants indicates preferential involvement of α integrin/ina-1 in GABAergic commissural development, without obvious involvement in cholinergic commissural development. The defects in GABAergic commissures of ina-1(gm144) mutants included both premature termination and guidance errors and were reversed by expression of wild type ina-1 under control of the native ina-1 promoter. Our results also show that α integrin/ina-1 is important for proper outgrowth and guidance of commissures from both embryonic and post-embryonic born GABAergic motor neurons, indicating an ongoing requirement for integrin through two phases of GABAergic neuron development. Our findings provide insights into neuron-specific roles for integrin that would not be predicted based solely upon expression analysis." @default.
• W2970469141 created "2019-09-05" @default.
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• W2970469141 date "2019-08-27" @default.
• W2970469141 modified "2023-10-16" @default.
• W2970469141 title "Integrins Have Cell-Type-Specific Roles in the Development of Motor Neuron Connectivity" @default.
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• W2970469141 doi "https://doi.org/10.3390/jdb7030017" @default.
• W2970469141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6787651" @default.
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• W2970469141 hasPublicationYear "2019" @default.
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