Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970491619> ?p ?o ?g. }
- W2970491619 endingPage "1541.e16" @default.
- W2970491619 startingPage "1526" @default.
- W2970491619 abstract "While knowledge of protein-protein interactions (PPIs) is critical for understanding virus-host relationships, limitations on the scalability of high-throughput methods have hampered their identification beyond a number of well-studied viruses. Here, we implement an in silico computational framework (pathogen host interactome prediction using structure similarity [P-HIPSTer]) that employs structural information to predict ∼282,000 pan viral-human PPIs with an experimental validation rate of ∼76%. In addition to rediscovering known biology, P-HIPSTer has yielded a series of new findings: the discovery of shared and unique machinery employed across human-infecting viruses, a likely role for ZIKV-ESR1 interactions in modulating viral replication, the identification of PPIs that discriminate between human papilloma viruses (HPVs) with high and low oncogenic potential, and a structure-enabled history of evolutionary selective pressure imposed on the human proteome. Further, P-HIPSTer enables discovery of previously unappreciated cellular circuits that act on human-infecting viruses and provides insight into experimentally intractable viruses." @default.
- W2970491619 created "2019-09-05" @default.
- W2970491619 creator A5004054730 @default.
- W2970491619 creator A5024400042 @default.
- W2970491619 creator A5024803439 @default.
- W2970491619 creator A5034730330 @default.
- W2970491619 creator A5036654109 @default.
- W2970491619 creator A5044234066 @default.
- W2970491619 creator A5056128255 @default.
- W2970491619 creator A5059624600 @default.
- W2970491619 creator A5065814558 @default.
- W2970491619 creator A5077589324 @default.
- W2970491619 date "2019-09-01" @default.
- W2970491619 modified "2023-10-16" @default.
- W2970491619 title "A Structure-Informed Atlas of Human-Virus Interactions" @default.
- W2970491619 cites W128985141 @default.
- W2970491619 cites W1524173502 @default.
- W2970491619 cites W1545235721 @default.
- W2970491619 cites W1552328480 @default.
- W2970491619 cites W1620032110 @default.
- W2970491619 cites W1644579564 @default.
- W2970491619 cites W1857453373 @default.
- W2970491619 cites W1900202044 @default.
- W2970491619 cites W1967034105 @default.
- W2970491619 cites W1968468219 @default.
- W2970491619 cites W1972673599 @default.
- W2970491619 cites W1973527515 @default.
- W2970491619 cites W1975622992 @default.
- W2970491619 cites W1977393774 @default.
- W2970491619 cites W1980439069 @default.
- W2970491619 cites W1988654342 @default.
- W2970491619 cites W1989216393 @default.
- W2970491619 cites W1991428150 @default.
- W2970491619 cites W1993073412 @default.
- W2970491619 cites W1993279060 @default.
- W2970491619 cites W1993656926 @default.
- W2970491619 cites W1996076856 @default.
- W2970491619 cites W1996423252 @default.
- W2970491619 cites W2001896897 @default.
- W2970491619 cites W2005121650 @default.
- W2970491619 cites W2012441269 @default.
- W2970491619 cites W2019495223 @default.
- W2970491619 cites W2021210077 @default.
- W2970491619 cites W2026583751 @default.
- W2970491619 cites W2028843689 @default.
- W2970491619 cites W2030018472 @default.
- W2970491619 cites W2035503835 @default.
- W2970491619 cites W2039473152 @default.
- W2970491619 cites W2040115433 @default.
- W2970491619 cites W2044417703 @default.
- W2970491619 cites W2050329134 @default.
- W2970491619 cites W2051210555 @default.
- W2970491619 cites W2051809501 @default.
- W2970491619 cites W2051939403 @default.
- W2970491619 cites W2053526761 @default.
- W2970491619 cites W2055043387 @default.
- W2970491619 cites W2057544171 @default.
- W2970491619 cites W2059807343 @default.
- W2970491619 cites W2060480439 @default.
- W2970491619 cites W2063901368 @default.
- W2970491619 cites W2067127476 @default.
- W2970491619 cites W2067911388 @default.
- W2970491619 cites W2068965703 @default.
- W2970491619 cites W2070319921 @default.
- W2970491619 cites W2072024663 @default.
- W2970491619 cites W2073658506 @default.
- W2970491619 cites W2074661820 @default.
- W2970491619 cites W2076269514 @default.
- W2970491619 cites W2079619043 @default.
- W2970491619 cites W2083747978 @default.
- W2970491619 cites W2088422296 @default.
- W2970491619 cites W2096525273 @default.
- W2970491619 cites W2099257109 @default.
- W2970491619 cites W2101196984 @default.
- W2970491619 cites W2101998831 @default.
- W2970491619 cites W2102475449 @default.
- W2970491619 cites W2103017472 @default.
- W2970491619 cites W2103546861 @default.
- W2970491619 cites W2107055030 @default.
- W2970491619 cites W2110335151 @default.
- W2970491619 cites W2111247428 @default.
- W2970491619 cites W2111973517 @default.
- W2970491619 cites W2113654464 @default.
- W2970491619 cites W2113778581 @default.
- W2970491619 cites W2114168715 @default.
- W2970491619 cites W2114938008 @default.
- W2970491619 cites W2115888213 @default.
- W2970491619 cites W2117119768 @default.
- W2970491619 cites W2119573232 @default.
- W2970491619 cites W2122914905 @default.
- W2970491619 cites W2123724865 @default.
- W2970491619 cites W2124177978 @default.
- W2970491619 cites W2124927273 @default.
- W2970491619 cites W2125957866 @default.
- W2970491619 cites W2130410032 @default.
- W2970491619 cites W2130479394 @default.
- W2970491619 cites W2131396616 @default.
- W2970491619 cites W2131858797 @default.