FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970588942> ?p ?o ?g. }

• W2970588942 endingPage "109274" @default.
• W2970588942 startingPage "109274" @default.
• W2970588942 abstract "This study aims to identify the feature genes associated with vascular invasion in hepatocellular carcinoma (HCC). Here, the RNA sequencing data related to vascular invasion in The Cancer Genome Atlas (TCGA) database, including 292 HCC patients with complete clinical data were included in our study as the training dataset for construction and E-TABM-36, including 41 HCC patients with complete clinical data was used as the validation dataset. Following data normalization, differentially expressed mRNA and copy number (CN) were selected between with and without vascular invasion samples. A support vector machine (SVM) classifier was constructed and validated in GSE9828 and GSE20017 datasets. Total 59 feature genes were found by the SVM classifier. Using Cox regression analysis, three clinical features, including Patholigic T, Stage and vascular invasion and 6 optimal prognostic genes, including ANO1, EPHX2, GFRA1, OLFM2, SERPINA10 and TKT were significantly correlated with prognosis. A risk score formula was developed to assess the prognostic value of 6 optimal prognostic genes, which were identified to possess the most remarkable correlation with overall survival in HCC patients. By performing in vitro experiments, we observed TKT was significantly increased, but OLFM2 was decreased in high metastatic potential HCC cell lines (SK-HEP-1 and MHCC-97 H) compared with low metastatic potential cell line Huh7 and normal human liver cell line LO2 using western blotting analysis. Knockdown of TKT in MHCC-97H or overexpression of OLFM2 in SK-HEP-1 significantly suppressed cell migration and invasion using transwell assays. Our results demonstrated that TKT and OLFM2 might be novel independent biomarkers for predicting survival based on the presence of vascular invasion in patients with HCC." @default.
• W2970588942 created "2019-09-05" @default.
• W2970588942 creator A5018962665 @default.
• W2970588942 creator A5053887136 @default.
• W2970588942 creator A5072173677 @default.
• W2970588942 creator A5085906127 @default.
• W2970588942 date "2019-10-01" @default.
• W2970588942 modified "2023-10-16" @default.
• W2970588942 title "Mining featured biomarkers associated with vascular invasion in HCC by bioinformatics analysis with TCGA RNA sequencing data" @default.
• W2970588942 cites W1497863497 @default.
• W2970588942 cites W1972825083 @default.
• W2970588942 cites W2006294797 @default.
• W2970588942 cites W2020541351 @default.
• W2970588942 cites W2036922484 @default.
• W2970588942 cites W2045389113 @default.
• W2970588942 cites W2057275128 @default.
• W2970588942 cites W2062567955 @default.
• W2970588942 cites W2069225806 @default.
• W2970588942 cites W2108671185 @default.
• W2970588942 cites W2120865735 @default.
• W2970588942 cites W2133465414 @default.
• W2970588942 cites W2142769937 @default.
• W2970588942 cites W2145665134 @default.
• W2970588942 cites W2146237899 @default.
• W2970588942 cites W2146512944 @default.
• W2970588942 cites W2158485828 @default.
• W2970588942 cites W2247007929 @default.
• W2970588942 cites W2253351601 @default.
• W2970588942 cites W2325902000 @default.
• W2970588942 cites W2340534421 @default.
• W2970588942 cites W2340686113 @default.
• W2970588942 cites W2473193283 @default.
• W2970588942 cites W2568329131 @default.
• W2970588942 cites W2586133997 @default.
• W2970588942 cites W2587718399 @default.
• W2970588942 cites W2601981958 @default.
• W2970588942 cites W2769166887 @default.
• W2970588942 cites W2793004401 @default.
• W2970588942 cites W2808641528 @default.
• W2970588942 cites W2884026312 @default.
• W2970588942 cites W2884204113 @default.
• W2970588942 cites W2895308016 @default.
• W2970588942 cites W2897879617 @default.
• W2970588942 cites W2900053374 @default.
• W2970588942 cites W2905158714 @default.
• W2970588942 doi "https://doi.org/10.1016/j.biopha.2019.109274" @default.
• W2970588942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31545220" @default.
• W2970588942 hasPublicationYear "2019" @default.
• W2970588942 type Work @default.
• W2970588942 sameAs 2970588942 @default.
• W2970588942 citedByCount "22" @default.
• W2970588942 countsByYear W29705889422020 @default.
• W2970588942 countsByYear W29705889422021 @default.
• W2970588942 countsByYear W29705889422022 @default.
• W2970588942 countsByYear W29705889422023 @default.
• W2970588942 crossrefType "journal-article" @default.
• W2970588942 hasAuthorship W2970588942A5018962665 @default.
• W2970588942 hasAuthorship W2970588942A5053887136 @default.
• W2970588942 hasAuthorship W2970588942A5072173677 @default.
• W2970588942 hasAuthorship W2970588942A5085906127 @default.
• W2970588942 hasBestOaLocation W29705889421 @default.
• W2970588942 hasConcept C104317684 @default.
• W2970588942 hasConcept C121608353 @default.
• W2970588942 hasConcept C126322002 @default.
• W2970588942 hasConcept C143998085 @default.
• W2970588942 hasConcept C173396325 @default.
• W2970588942 hasConcept C2778019345 @default.
• W2970588942 hasConcept C2779013556 @default.
• W2970588942 hasConcept C3020478367 @default.
• W2970588942 hasConcept C502942594 @default.
• W2970588942 hasConcept C50382708 @default.
• W2970588942 hasConcept C54355233 @default.
• W2970588942 hasConcept C60644358 @default.
• W2970588942 hasConcept C70721500 @default.
• W2970588942 hasConcept C71924100 @default.
• W2970588942 hasConcept C86803240 @default.
• W2970588942 hasConceptScore W2970588942C104317684 @default.
• W2970588942 hasConceptScore W2970588942C121608353 @default.
• W2970588942 hasConceptScore W2970588942C126322002 @default.
• W2970588942 hasConceptScore W2970588942C143998085 @default.
• W2970588942 hasConceptScore W2970588942C173396325 @default.
• W2970588942 hasConceptScore W2970588942C2778019345 @default.
• W2970588942 hasConceptScore W2970588942C2779013556 @default.
• W2970588942 hasConceptScore W2970588942C3020478367 @default.
• W2970588942 hasConceptScore W2970588942C502942594 @default.
• W2970588942 hasConceptScore W2970588942C50382708 @default.
• W2970588942 hasConceptScore W2970588942C54355233 @default.
• W2970588942 hasConceptScore W2970588942C60644358 @default.
• W2970588942 hasConceptScore W2970588942C70721500 @default.
• W2970588942 hasConceptScore W2970588942C71924100 @default.
• W2970588942 hasConceptScore W2970588942C86803240 @default.
• W2970588942 hasLocation W29705889421 @default.
• W2970588942 hasLocation W29705889422 @default.
• W2970588942 hasOpenAccess W2970588942 @default.
• W2970588942 hasPrimaryLocation W29705889421 @default.
• W2970588942 hasRelatedWork W2028884946 @default.
• W2970588942 hasRelatedWork W2054174996 @default.
• W2970588942 hasRelatedWork W2889664504 @default.

• next