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• W2970594694 endingPage "e0216261" @default.
• W2970594694 startingPage "e0216261" @default.
• W2970594694 abstract "Focal segmental glomerulosclerosis is a major cause of end stage renal disease. Many patients prove unresponsive to available therapies. An improved understanding of the molecular basis of the disease process could provide insights leading to novel therapeutic approaches. In this study we carried out an RNA-seq analysis of the altered gene expression patterns of podocytes, mesangial cells and glomerular endothelial cells of the bigenic Cd2ap+/-, Fyn-/- mutant mouse model of FSGS. In the podocytes we observed upregulation of many genes related to the Tgfβ family/pathway, including Gdnf, Tgfβ1, Tgfβ2, Snai2, Vegfb, Bmp4, and Tnc. The mutant podocytes also showed upregulation of Acta2, a marker of smooth muscle and associated with myofibroblasts, which are implicated in driving fibrosis. GO analysis of the podocyte upregulated genes identified elevated protein kinase activity, increased expression of growth factors, and negative regulation of cell adhesion, perhaps related to the observed podocyte loss. Both podocytes and mesangial cells showed strong upregulation of aldehyde dehydrogenase genes involved in the synthesis of retinoic acid. Similarly, the Cd2ap+/-, Fyn-/- mesangial cells, as well as podocytes in other genetic models, and the glomeruli of human FSGS patients, all show upregulation of the serine protease Prss23, with the common thread suggesting important functionality. Another gene with strong upregulation in the Cd2ap+/-, Fyn-/- mutant mesangial cells as well as multiple other mutant mouse models of FSGS was thrombospondin, which activates the secreted inactive form of Tgfβ. The Cd2ap+/-, Fyn-/- mutant endothelial cells showed elevated expression of genes involved in cell proliferation, angioblast migration, angiogenesis, and neovasculature, all consistent with the formation of new blood vessels in the diseased glomerulus. The resulting global definition of the perturbed molecular pathways in the three major cell types of the mutant glomerulus provide deeper understanding of the molecular pathogenic pathways." @default.
• W2970594694 created "2019-09-05" @default.
• W2970594694 creator A5010341293 @default.
• W2970594694 creator A5017002641 @default.
• W2970594694 creator A5018880628 @default.
• W2970594694 creator A5063310059 @default.
• W2970594694 date "2019-08-28" @default.
• W2970594694 modified "2023-10-16" @default.
• W2970594694 title "A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells" @default.
• W2970594694 cites W145859498 @default.
• W2970594694 cites W1942399788 @default.
• W2970594694 cites W1965028480 @default.
• W2970594694 cites W1972845034 @default.
• W2970594694 cites W1975318062 @default.
• W2970594694 cites W1978127755 @default.
• W2970594694 cites W1985779907 @default.
• W2970594694 cites W1989037081 @default.
• W2970594694 cites W1997309422 @default.
• W2970594694 cites W1998996047 @default.
• W2970594694 cites W2000637899 @default.
• W2970594694 cites W2009132304 @default.
• W2970594694 cites W2012446318 @default.
• W2970594694 cites W2013055426 @default.
• W2970594694 cites W2014745165 @default.
• W2970594694 cites W2014868340 @default.
• W2970594694 cites W2017789182 @default.
• W2970594694 cites W2018274314 @default.
• W2970594694 cites W2025232712 @default.
• W2970594694 cites W2025620210 @default.
• W2970594694 cites W2027113588 @default.
• W2970594694 cites W2031098987 @default.
• W2970594694 cites W2034598927 @default.
• W2970594694 cites W2036440007 @default.
• W2970594694 cites W2036692587 @default.
• W2970594694 cites W2037910803 @default.
• W2970594694 cites W2040670636 @default.
• W2970594694 cites W2042921682 @default.
• W2970594694 cites W2047907490 @default.
• W2970594694 cites W2059114286 @default.
• W2970594694 cites W2061519721 @default.
• W2970594694 cites W2062268212 @default.
• W2970594694 cites W2066768427 @default.
• W2970594694 cites W2070461035 @default.
• W2970594694 cites W2074201586 @default.
• W2970594694 cites W2078060536 @default.
• W2970594694 cites W2082479585 @default.
• W2970594694 cites W2085574022 @default.
• W2970594694 cites W2087749727 @default.
• W2970594694 cites W2087961733 @default.
• W2970594694 cites W2093932304 @default.
• W2970594694 cites W2094553248 @default.
• W2970594694 cites W2098823303 @default.
• W2970594694 cites W2101410412 @default.
• W2970594694 cites W2115096573 @default.
• W2970594694 cites W2118013290 @default.
• W2970594694 cites W2119450370 @default.
• W2970594694 cites W2120133277 @default.
• W2970594694 cites W2122770875 @default.
• W2970594694 cites W2125087346 @default.
• W2970594694 cites W2133992677 @default.
• W2970594694 cites W2137096226 @default.
• W2970594694 cites W2139797791 @default.
• W2970594694 cites W2144691802 @default.
• W2970594694 cites W2152253630 @default.
• W2970594694 cites W2152723471 @default.
• W2970594694 cites W2153361366 @default.
• W2970594694 cites W2157101382 @default.
• W2970594694 cites W2161245712 @default.
• W2970594694 cites W2163605874 @default.
• W2970594694 cites W2164334076 @default.
• W2970594694 cites W2169453638 @default.
• W2970594694 cites W2171543179 @default.
• W2970594694 cites W2171936044 @default.
• W2970594694 cites W2203146928 @default.
• W2970594694 cites W2301137156 @default.
• W2970594694 cites W2405412838 @default.
• W2970594694 cites W2411779324 @default.
• W2970594694 cites W2419274075 @default.
• W2970594694 cites W2531928944 @default.
• W2970594694 cites W2551462252 @default.
• W2970594694 cites W2592877394 @default.
• W2970594694 cites W2593771998 @default.
• W2970594694 cites W2768688513 @default.
• W2970594694 cites W4210965751 @default.
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• W2970594694 doi "https://doi.org/10.1371/journal.pone.0216261" @default.
• W2970594694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6713350" @default.
• W2970594694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31461442" @default.
• W2970594694 hasPublicationYear "2019" @default.
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