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- W2970640905 endingPage "158513" @default.
- W2970640905 startingPage "158513" @default.
- W2970640905 abstract "The biosynthetic pathways for most lipophilic metabolites share several common principles. These substances are built almost exclusively from acetyl-CoA as the donor for the carbon scaffold and NADPH is required for the reductive steps during biosynthesis. Due to their hydrophobicity, the end products are sequestered into the same cellular compartment, the lipid droplet. In this review, we will summarize the efforts in the metabolic engineering of yeasts for the production of two major hydrophobic substance classes, fatty acid-based lipids and isoprenoids, with regard to these common aspects. We will compare and discuss the results of genetic engineering strategies to construct strains with enhanced synthesis of the precursor acetyl-CoA and with modified redox metabolism for improved NADPH supply. We will also discuss the role of the lipid droplet in the storage of the hydrophobic product and review the strategies to either optimize this organelle for higher capacity or to achieve excretion of the product into the medium." @default.
- W2970640905 created "2019-09-05" @default.
- W2970640905 creator A5017030918 @default.
- W2970640905 creator A5085513772 @default.
- W2970640905 date "2019-12-01" @default.
- W2970640905 modified "2023-09-27" @default.
- W2970640905 title "Common aspects in the engineering of yeasts for fatty acid- and isoprene-based products" @default.
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