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- W2970658856 abstract "There is experimental and observational evidence that the cells of the leukemic clone in acute myeloid leukemia (AML) have different phenotypes even though they share the same somatic mutations. The organization of the malignant clone in AML has many similarities to normal hematopoiesis, with leukemia stem cells (LSCs) that sustain leukemia and give rise to more differentiated cells. LSCs, similar to normal hematopoietic stem cells (HSCs), are those cells that are able to give rise to a new leukemic clone when transplanted into a recipient. The cell of origin of leukemia (COL) is defined as the normal cell that is able to transform into a leukemia cell. Current evidence suggests that the COL is distinct from the LSC. Here, we will review the current knowledge about LSCs and the COL in AML." @default.
- W2970658856 created "2019-09-05" @default.
- W2970658856 creator A5024546244 @default.
- W2970658856 creator A5058099757 @default.
- W2970658856 date "2019-08-31" @default.
- W2970658856 modified "2023-10-17" @default.
- W2970658856 title "The cell of origin and the leukemia stem cell in acute myeloid leukemia" @default.
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- W2970658856 doi "https://doi.org/10.1002/gcc.22805" @default.
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