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- W2970666095 abstract "METCAM/MUC18, a component of cellular membrane, is a cell adhesion molecule (CAM) in the Ig-like gene super-family. It is capable of carrying out general functions of CAMs, such as performing intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, interacting with various signaling pathways, and regulating social behaviors of cells. METCAM/MUC18 plays the tumor suppressor function in some cancers, such as colorectal cancer, nasopharyngeal carcinoma type I, one mouse melanoma subline K1735-9, ovarian cancer, pancreatic cancer, prostate cancer PC-3 cell line, and perhaps hemangioma. Possible mechanism in the METCAM/MUC18-mediated tumor suppression is proposed. By taking advantage of the tumor suppressor function of METCAM/MUC18, recombinant METCAM/MUC18 proteins and other derived products may be used as therapeutic agents to treat these cancers." @default.
- W2970666095 created "2019-09-05" @default.
- W2970666095 creator A5050027982 @default.
- W2970666095 date "2019-09-11" @default.
- W2970666095 modified "2023-10-03" @default.
- W2970666095 title "METCAM/MUC18: A Novel Tumor Suppressor for Some Cancers" @default.
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- W2970666095 doi "https://doi.org/10.5772/intechopen.86271" @default.
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