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- W2970670654 endingPage "266" @default.
- W2970670654 startingPage "253" @default.
- W2970670654 abstract "Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production and coordinates erythropoiesis with iron metabolism. Small molecule inhibitors of prolyl hydroxylase domain dioxygenases (HIF-PHI [prolyl hydroxylase inhibitor]) stimulate the production of endogenous erythropoietin and improve iron metabolism resulting in efficacious anemia management in patients with CKD. Three oral HIF-PHIs-daprodustat, roxadustat, and vadadustat-have now advanced to global phase III clinical development culminating in the recent licensing of roxadustat for oral anemia therapy in China. Here, we survey current clinical experience with HIF-PHIs, discuss potential therapeutic advantages, and deliberate over safety concerns regarding long-term administration in patients with renal anemia." @default.
- W2970670654 created "2019-09-05" @default.
- W2970670654 creator A5047016559 @default.
- W2970670654 creator A5071889215 @default.
- W2970670654 date "2019-07-01" @default.
- W2970670654 modified "2023-10-14" @default.
- W2970670654 title "Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience" @default.
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