FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970702943> ?p ?o ?g. }

• W2970702943 abstract "DNA methylation is an epigenetic modification consisting in the addition of a methyl group to the position 5 of a cytosine in a CpG context. In normal mammalian cells, while CpG islands, mostly concentrated at promoter regions, are protected from DNA methylation, intergenic and repetitive regions are normally hypermethylated. In cancer cells, a massive change in the global methylation pattern occurs. Intergenic and repetitive regions of the genome become hypomethylated leading to the reactivation of transposable elements and genomic instability. In contrast, a focal hypermethylation of CpG islands at promoter regions occurs and it is normally associated to gene expression downregulation. Thus, aberrant DNA methylation is one of the most striking features of cancer cells and several studies have demonstrated that cancer-specific methylation patterns exist. For this reason, DNA methylation represents an extremely useful biomarker for several applications, including cancer risk definition, prediction of clinical outcomes, treatment response and cancer relapse. Finally, the association between DNA methylation and gene expression, although notoriously recognized, is not yet fully known, and the study of DNA methylation alterations in cancer and their consequences can help elucidate the mechanisms underlying this relationship." @default.
• W2970702943 created "2019-09-05" @default.
• W2970702943 creator A5005637897 @default.
• W2970702943 creator A5067394498 @default.
• W2970702943 date "2019-01-01" @default.
• W2970702943 modified "2023-09-26" @default.
• W2970702943 title "CpG Islands Methylation Alterations in Cancer: Functionally Intriguing Security Locks, Useful Early Tumor Biomarkers" @default.
• W2970702943 cites W1504303645 @default.
• W2970702943 cites W1855267957 @default.
• W2970702943 cites W1965050427 @default.
• W2970702943 cites W1965722916 @default.
• W2970702943 cites W1969670934 @default.
• W2970702943 cites W1984807040 @default.
• W2970702943 cites W1989068609 @default.
• W2970702943 cites W1989578834 @default.
• W2970702943 cites W1990711772 @default.
• W2970702943 cites W2014432992 @default.
• W2970702943 cites W2029868343 @default.
• W2970702943 cites W2042087070 @default.
• W2970702943 cites W2053421436 @default.
• W2970702943 cites W2061891352 @default.
• W2970702943 cites W2062093164 @default.
• W2970702943 cites W2064587649 @default.
• W2970702943 cites W2068351971 @default.
• W2970702943 cites W2068549238 @default.
• W2970702943 cites W2069443403 @default.
• W2970702943 cites W2072659813 @default.
• W2970702943 cites W2077919940 @default.
• W2970702943 cites W2093531978 @default.
• W2970702943 cites W2096330673 @default.
• W2970702943 cites W2101491950 @default.
• W2970702943 cites W2110079312 @default.
• W2970702943 cites W2113467627 @default.
• W2970702943 cites W2120439635 @default.
• W2970702943 cites W2127821100 @default.
• W2970702943 cites W2141410747 @default.
• W2970702943 cites W2152203766 @default.
• W2970702943 cites W2158143138 @default.
• W2970702943 cites W2167548363 @default.
• W2970702943 cites W2170210082 @default.
• W2970702943 cites W2212193413 @default.
• W2970702943 cites W2472461999 @default.
• W2970702943 cites W2760986701 @default.
• W2970702943 cites W2791931432 @default.
• W2970702943 cites W2793056860 @default.
• W2970702943 cites W2802211415 @default.
• W2970702943 cites W4213257593 @default.
• W2970702943 cites W2045181115 @default.
• W2970702943 doi "https://doi.org/10.1007/978-3-030-14792-1_3" @default.
• W2970702943 hasPublicationYear "2019" @default.
• W2970702943 type Work @default.
• W2970702943 sameAs 2970702943 @default.
• W2970702943 citedByCount "0" @default.
• W2970702943 crossrefType "book-chapter" @default.
• W2970702943 hasAuthorship W2970702943A5005637897 @default.
• W2970702943 hasAuthorship W2970702943A5067394498 @default.
• W2970702943 hasConcept C101762097 @default.
• W2970702943 hasConcept C104317684 @default.
• W2970702943 hasConcept C114691636 @default.
• W2970702943 hasConcept C121608353 @default.
• W2970702943 hasConcept C121912465 @default.
• W2970702943 hasConcept C136953436 @default.
• W2970702943 hasConcept C140173407 @default.
• W2970702943 hasConcept C150194340 @default.
• W2970702943 hasConcept C163002167 @default.
• W2970702943 hasConcept C190727270 @default.
• W2970702943 hasConcept C33288867 @default.
• W2970702943 hasConcept C41091548 @default.
• W2970702943 hasConcept C502942594 @default.
• W2970702943 hasConcept C54355233 @default.
• W2970702943 hasConcept C86803240 @default.
• W2970702943 hasConceptScore W2970702943C101762097 @default.
• W2970702943 hasConceptScore W2970702943C104317684 @default.
• W2970702943 hasConceptScore W2970702943C114691636 @default.
• W2970702943 hasConceptScore W2970702943C121608353 @default.
• W2970702943 hasConceptScore W2970702943C121912465 @default.
• W2970702943 hasConceptScore W2970702943C136953436 @default.
• W2970702943 hasConceptScore W2970702943C140173407 @default.
• W2970702943 hasConceptScore W2970702943C150194340 @default.
• W2970702943 hasConceptScore W2970702943C163002167 @default.
• W2970702943 hasConceptScore W2970702943C190727270 @default.
• W2970702943 hasConceptScore W2970702943C33288867 @default.
• W2970702943 hasConceptScore W2970702943C41091548 @default.
• W2970702943 hasConceptScore W2970702943C502942594 @default.
• W2970702943 hasConceptScore W2970702943C54355233 @default.
• W2970702943 hasConceptScore W2970702943C86803240 @default.
• W2970702943 hasLocation W29707029431 @default.
• W2970702943 hasOpenAccess W2970702943 @default.
• W2970702943 hasPrimaryLocation W29707029431 @default.
• W2970702943 hasRelatedWork W1828757596 @default.
• W2970702943 hasRelatedWork W2047224758 @default.
• W2970702943 hasRelatedWork W2112345478 @default.
• W2970702943 hasRelatedWork W2121654623 @default.
• W2970702943 hasRelatedWork W2130869774 @default.
• W2970702943 hasRelatedWork W2144727750 @default.
• W2970702943 hasRelatedWork W2414305690 @default.
• W2970702943 hasRelatedWork W2555083638 @default.
• W2970702943 hasRelatedWork W2942230700 @default.
• W2970702943 hasRelatedWork W970881 @default.
• W2970702943 isParatext "false" @default.

• next