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- W2970730020 abstract "For several decades cholesterol and cholic acid have been added to diets to produce hypercholesterolemia and atherosclerosis in experimental animals. These experiments have contributed to the development of the hypothesis that dietary lipid contributes to the development of atherosclerosis and ischemic heart disease. Because of a new hypothesis that absolute or relative deficiency of copper is important in the etiology of this disease, diets of rats were supplemented with copper to determine whether or not supplementation could decrease the hypercholesterolemia induced by dietary cholesterol and cholic acid. Extra dietary copper diminished or abolished this hypercholesterolemic effect in two experiments. Dietary cholesterol and cholic acid caused a decrease in liver copper, which could be abolished by extra dietary copper, and an increase in the dietary requirement for copper. These results forge a link between the lipid hypothesis and the hypothesis involving copper metabolism on the origin of ischemic heart disease. Interpretations of experiments involving dietary cholesterol and cholic acid may require revision." @default.
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- W2970730020 date "1982-01-01" @default.
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- W2970730020 title "Metabolic interactions among cholesterol, cholic acid and copper" @default.
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