FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970814967> ?p ?o ?g. }

• W2970814967 endingPage "1787" @default.
• W2970814967 startingPage "1778" @default.
• W2970814967 abstract "Abstract STUDY QUESTION What is the number of oocytes where the maximum cumulative live birth rate per aspiration (CLBR) is observed during ART in women of different ages? SUMMARY ANSWER The maximum CLBR was observed when around 25 oocytes were retrieved in women between 18–35 years of age, around 9 oocytes in women more than 45 years of age and continued to increase beyond 30 oocytes in women between 36–44 years of age. WHAT IS KNOWN ALREADY The live birth rate per fresh or frozen/thaw embryo transfer (FET) procedure has traditionally been the main measure of ART success. However, with the introduction of highly efficient embryo cryopreservation methods, CLBR encompassing live delivery outcomes from the fresh and all subsequent FET following a single ovarian stimulation and oocyte collection is increasingly viewed as a more meaningful measure of treatment success. There is evidence suggesting that larger oocyte yields are associated with increased likelihood of cumulative live birth per aspiration. Whether this association is the same across female ages has not yet been properly investigated. STUDY DESIGN, SIZE, DURATION This is a large retrospective population-based cohort study using data from the Australian and New Zealand Assisted Reproduction Database (ANZARD). ANZARD contains information from all ART treatment cycles carried out in all fertility centres in Australia and New Zealand. Overall, 221 221 autologous oocyte aspiration cycles carried out between January 2009 to December 2015 were included in the analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS Cumulative live birth per aspiration was defined as at least one liveborn baby at ≥20 weeks gestation resulting from an ART aspiration cycle, including all fresh and FET resulting from the associated ovarian stimulation, until one live birth occurred or all embryos were used. Cycles where no oocytes were retrieved were excluded from analysis as there is no possibility of live birth. Analyses of data were performed using generalized estimating equations to account for the clustered nature of data (multiple cycles undertaken by a woman). Univariate and multivariable regression analysis was performed to identify and adjust for factors known to independently affect cumulative live birth per aspiration. An interaction term between female age and the number of oocytes retrieved was included to assess whether the age of the women was associated with a different optimal number of oocytes to achieve at least one live birth from an aspiration cycle (i.e. the effect-modifying role of female age). The likelihood of cumulative live birth per aspiration was calculated as odds ratios (ORs) with 95% CI. MAIN RESULTS AND THE ROLE OF CHANCE The median number of oocytes retrieved was 7 (interquartile range, 4–12) and median age of patients was 36 (interquartile range, 33–40). The overall CLBR was 32.2%. The results from the multivariable regression analysis showed that the number of oocytes retrieved remained a significant predictor (P < 0.001) of cumulative live birth per aspiration after adjusting for female age, parity and cycle count. Compared to the reference group of 10–14 oocytes retrieved, the adjusted odds for cumulative live birth per aspiration increased with the number of oocytes retrieved: 1–3 oocytes, 0.21 (95% CI, 0.20–0.22); 4–9 oocytes, 0.56 (95% CI, 0.55–0.58); 15–19 oocytes, 1.38 (95% CI, 1.34–1.43); 20–24 oocytes, 1.75 (95% CI, 1.67–1.84); and 2.10 (95% CI, 1.96–2.25) with more than 25 oocytes. After stratifying by female age group, the rate of increase in CLBR per additional oocyte retrieved was lower in the older age groups, indicating that higher oocyte yields were more beneficial in younger women. CLBR of patients in the <30 years and 30–34 years age groups appeared to reach a plateau (with only minimal increase in CLBR per additional oocyte retrieved) after retrieval of 25 oocytes at 73% and 72%, respectively, while CLBR of patients in the 35–39 years and 40–44 years age groups continued to increase with higher oocyte yields, reaching 68% and 40%, respectively, when 30 or more oocytes were retrieved. CLBR of patients aged 45 years and above remained consistently below 5%. Findings suggest that the number of oocytes retrieved where CLBR appears to be maximized is around 25 in women between 18–35 years, more than 30 in women between 36–44 years and around 9 in women 45 years and older. However, results for women aged 45 years and older may not be as robust due to the relatively small sample size available in this age group. LIMITATIONS, REASONS FOR CAUTION As with all large retrospective database studies, there are potential confounders that cannot be accounted for. Despite the current study being based on complete ascertainment of ART cycles across two countries, ovarian stimulation protocols, oocyte quality parameters and a number of important patient characteristics are not collected by ANZARD. Additionally, a small number of cycles were available for women over 45 years yielding more than 15 oocytes, making these estimates unreliable. WIDER IMPLICATIONS OF THE FINDINGS The results from this study demonstrate that the number of oocytes retrieved where the maximum CLBR is observed during ART is dependent on female age. This provides information for clinicians and patients to understand the modifying effect of age on the number of oocytes retrieved and the likelihood of success with ART. STUDY FUNDING/COMPETING INTEREST(S) No external funding was used for this study. The Fertility Society of Australia funds the National Perinatal Epidemiology and Statistics Unit to manage ANZARD and conduct national reporting of ART in Australia and New Zealand. Associate Professor Georgina Chambers (G.C.) is employed by the University of New South Wales (UNSW) and is director of the National Perinatal Epidemiology and Statistics Unit at UNSW. G.C. was also a paid member of the Australian governments Medicare Benefits Scheme taskforce on assisted reproductive technologies in 2017." @default.
• W2970814967 created "2019-09-05" @default.
• W2970814967 creator A5013850174 @default.
• W2970814967 creator A5037796650 @default.
• W2970814967 creator A5040486071 @default.
• W2970814967 creator A5054418515 @default.
• W2970814967 creator A5054726657 @default.
• W2970814967 date "2019-08-09" @default.
• W2970814967 modified "2023-10-18" @default.
• W2970814967 title "The number of oocytes associated with maximum cumulative live birth rates per aspiration depends on female age: a population study of 221 221 treatment cycles" @default.
• W2970814967 cites W1968759636 @default.
• W2970814967 cites W1970139299 @default.
• W2970814967 cites W2004451047 @default.
• W2970814967 cites W2016202940 @default.
• W2970814967 cites W2033673768 @default.
• W2970814967 cites W2117470501 @default.
• W2970814967 cites W2136338714 @default.
• W2970814967 cites W2138674040 @default.
• W2970814967 cites W2142975953 @default.
• W2970814967 cites W2143564115 @default.
• W2970814967 cites W2170309753 @default.
• W2970814967 cites W2170908711 @default.
• W2970814967 cites W2558678606 @default.
• W2970814967 cites W2737859857 @default.
• W2970814967 cites W2739504526 @default.
• W2970814967 cites W2767640303 @default.
• W2970814967 cites W2891240559 @default.
• W2970814967 cites W2901915783 @default.
• W2970814967 cites W2994316232 @default.
• W2970814967 doi "https://doi.org/10.1093/humrep/dez100" @default.
• W2970814967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31398253" @default.
• W2970814967 hasPublicationYear "2019" @default.
• W2970814967 type Work @default.
• W2970814967 sameAs 2970814967 @default.
• W2970814967 citedByCount "47" @default.
• W2970814967 countsByYear W29708149672020 @default.
• W2970814967 countsByYear W29708149672021 @default.
• W2970814967 countsByYear W29708149672022 @default.
• W2970814967 countsByYear W29708149672023 @default.
• W2970814967 crossrefType "journal-article" @default.
• W2970814967 hasAuthorship W2970814967A5013850174 @default.
• W2970814967 hasAuthorship W2970814967A5037796650 @default.
• W2970814967 hasAuthorship W2970814967A5040486071 @default.
• W2970814967 hasAuthorship W2970814967A5054418515 @default.
• W2970814967 hasAuthorship W2970814967A5054726657 @default.
• W2970814967 hasConcept C131872663 @default.
• W2970814967 hasConcept C160099875 @default.
• W2970814967 hasConcept C2777688143 @default.
• W2970814967 hasConcept C2778279030 @default.
• W2970814967 hasConcept C2779234561 @default.
• W2970814967 hasConcept C2908647359 @default.
• W2970814967 hasConcept C29456083 @default.
• W2970814967 hasConcept C500014431 @default.
• W2970814967 hasConcept C518429986 @default.
• W2970814967 hasConcept C54355233 @default.
• W2970814967 hasConcept C71924100 @default.
• W2970814967 hasConcept C86803240 @default.
• W2970814967 hasConcept C99454951 @default.
• W2970814967 hasConceptScore W2970814967C131872663 @default.
• W2970814967 hasConceptScore W2970814967C160099875 @default.
• W2970814967 hasConceptScore W2970814967C2777688143 @default.
• W2970814967 hasConceptScore W2970814967C2778279030 @default.
• W2970814967 hasConceptScore W2970814967C2779234561 @default.
• W2970814967 hasConceptScore W2970814967C2908647359 @default.
• W2970814967 hasConceptScore W2970814967C29456083 @default.
• W2970814967 hasConceptScore W2970814967C500014431 @default.
• W2970814967 hasConceptScore W2970814967C518429986 @default.
• W2970814967 hasConceptScore W2970814967C54355233 @default.
• W2970814967 hasConceptScore W2970814967C71924100 @default.
• W2970814967 hasConceptScore W2970814967C86803240 @default.
• W2970814967 hasConceptScore W2970814967C99454951 @default.
• W2970814967 hasIssue "9" @default.
• W2970814967 hasLocation W29708149671 @default.
• W2970814967 hasLocation W29708149672 @default.
• W2970814967 hasOpenAccess W2970814967 @default.
• W2970814967 hasPrimaryLocation W29708149671 @default.
• W2970814967 hasRelatedWork W2093031677 @default.
• W2970814967 hasRelatedWork W2396234584 @default.
• W2970814967 hasRelatedWork W2465787575 @default.
• W2970814967 hasRelatedWork W2580552437 @default.
• W2970814967 hasRelatedWork W2770375764 @default.
• W2970814967 hasRelatedWork W2894442303 @default.
• W2970814967 hasRelatedWork W2911250245 @default.
• W2970814967 hasRelatedWork W3029602502 @default.
• W2970814967 hasRelatedWork W3046646871 @default.
• W2970814967 hasRelatedWork W3118775609 @default.
• W2970814967 hasVolume "34" @default.
• W2970814967 isParatext "false" @default.
• W2970814967 isRetracted "false" @default.
• W2970814967 magId "2970814967" @default.
• W2970814967 workType "article" @default.