Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970822705> ?p ?o ?g. }
- W2970822705 endingPage "665" @default.
- W2970822705 startingPage "651" @default.
- W2970822705 abstract "Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the skeleton. These cells work in harmony with osteoclasts, which resorb bone, in a continuous cycle that occurs throughout life. The unique function of osteoblasts requires substantial amounts of energy production, particularly during states of new bone formation and remodelling. Over the last 15 years, studies have shown that osteoblasts secrete endocrine factors that integrate the metabolic requirements of bone formation with global energy balance through the regulation of insulin production, feeding behaviour and adipose tissue metabolism. In this article, we summarize the current understanding of three osteoblast-derived metabolic hormones (osteocalcin, lipocalin and sclerostin) and the clinical evidence that suggests the relevance of these pathways in humans, while also discussing the necessity of specific energy substrates (glucose, fatty acids and amino acids) to fuel bone formation and promote osteoblast differentiation. Osteoblasts synthesize bone matrix and work in harmony with bone-resorbing osteoclasts in a continuous bone remodelling cycle. This Review discusses three known osteoblast-secreted endocrine factors (osteocalcin, lipocalin and sclerostin) and highlights how these hormones integrate the metabolic requirements of bone formation with respect to whole-body metabolism." @default.
- W2970822705 created "2019-09-05" @default.
- W2970822705 creator A5025822097 @default.
- W2970822705 creator A5036526470 @default.
- W2970822705 creator A5070815712 @default.
- W2970822705 creator A5087702148 @default.
- W2970822705 date "2019-08-28" @default.
- W2970822705 modified "2023-10-16" @default.
- W2970822705 title "The role of osteoblasts in energy homeostasis" @default.
- W2970822705 cites W119911077 @default.
- W2970822705 cites W1262925301 @default.
- W2970822705 cites W145654320 @default.
- W2970822705 cites W1479969474 @default.
- W2970822705 cites W1501939485 @default.
- W2970822705 cites W1509651969 @default.
- W2970822705 cites W1539015398 @default.
- W2970822705 cites W1596224076 @default.
- W2970822705 cites W1598973150 @default.
- W2970822705 cites W1655626708 @default.
- W2970822705 cites W1757602702 @default.
- W2970822705 cites W1766726626 @default.
- W2970822705 cites W1901404250 @default.
- W2970822705 cites W1929564265 @default.
- W2970822705 cites W1955614201 @default.
- W2970822705 cites W1956327946 @default.
- W2970822705 cites W1963673901 @default.
- W2970822705 cites W1963690512 @default.
- W2970822705 cites W1965682512 @default.
- W2970822705 cites W1965696823 @default.
- W2970822705 cites W1967144822 @default.
- W2970822705 cites W1967819106 @default.
- W2970822705 cites W1969024827 @default.
- W2970822705 cites W1970357295 @default.
- W2970822705 cites W1970728706 @default.
- W2970822705 cites W1971400919 @default.
- W2970822705 cites W1971887776 @default.
- W2970822705 cites W1980468305 @default.
- W2970822705 cites W1980740451 @default.
- W2970822705 cites W1981284961 @default.
- W2970822705 cites W1982395713 @default.
- W2970822705 cites W1985076554 @default.
- W2970822705 cites W1986371480 @default.
- W2970822705 cites W1989889975 @default.
- W2970822705 cites W1990357124 @default.
- W2970822705 cites W1992208052 @default.
- W2970822705 cites W1992382649 @default.
- W2970822705 cites W1992547263 @default.
- W2970822705 cites W1993983990 @default.
- W2970822705 cites W1996365670 @default.
- W2970822705 cites W1997748417 @default.
- W2970822705 cites W1997801717 @default.
- W2970822705 cites W2000893893 @default.
- W2970822705 cites W2000970827 @default.
- W2970822705 cites W2001956022 @default.
- W2970822705 cites W2001957914 @default.
- W2970822705 cites W2002198698 @default.
- W2970822705 cites W2002885590 @default.
- W2970822705 cites W2007283880 @default.
- W2970822705 cites W2008847140 @default.
- W2970822705 cites W2008949718 @default.
- W2970822705 cites W2013339414 @default.
- W2970822705 cites W2014566205 @default.
- W2970822705 cites W2014922493 @default.
- W2970822705 cites W2015351957 @default.
- W2970822705 cites W2018361036 @default.
- W2970822705 cites W2019864056 @default.
- W2970822705 cites W2021550981 @default.
- W2970822705 cites W2022121540 @default.
- W2970822705 cites W2022497833 @default.
- W2970822705 cites W2024155257 @default.
- W2970822705 cites W2027964931 @default.
- W2970822705 cites W2030960222 @default.
- W2970822705 cites W2035140534 @default.
- W2970822705 cites W2035189089 @default.
- W2970822705 cites W2037750372 @default.
- W2970822705 cites W2038553863 @default.
- W2970822705 cites W2038607522 @default.
- W2970822705 cites W2041638197 @default.
- W2970822705 cites W2041712675 @default.
- W2970822705 cites W2042241553 @default.
- W2970822705 cites W2044151997 @default.
- W2970822705 cites W2046583479 @default.
- W2970822705 cites W2047761422 @default.
- W2970822705 cites W2050217226 @default.
- W2970822705 cites W2052218228 @default.
- W2970822705 cites W2057961407 @default.
- W2970822705 cites W2060424229 @default.
- W2970822705 cites W2061922416 @default.
- W2970822705 cites W2062721270 @default.
- W2970822705 cites W2063776845 @default.
- W2970822705 cites W2064196330 @default.
- W2970822705 cites W2066217988 @default.
- W2970822705 cites W2066342271 @default.
- W2970822705 cites W2067171323 @default.
- W2970822705 cites W2068509699 @default.
- W2970822705 cites W2068873678 @default.
- W2970822705 cites W2068916684 @default.
- W2970822705 cites W2069641334 @default.