FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970830310> ?p ?o ?g. }

• W2970830310 endingPage "134140" @default.
• W2970830310 startingPage "134140" @default.
• W2970830310 abstract "Organotin compounds are the ubiquitous environmental pollutants due to their wide industrial and agricultural applications and unexpected releasing into the environment, which show characteristic of endocrine disruptors to interfere with the synthesis, receptor binding or action of endogenous-hormones. Organotin pesticides (OTPs) are used in agriculture and may impact endocrine functions on organisms. Thyroid hormones (THs) play fundamental roles in regulating the basal metabolism and energy balance, while thyroid function can be impaired by environmental contaminants. Therefore, it is crucial to clarify the effects and mechanisms of OTPs on hypothalamus-pituitary-thyroid (HPT) axis. In this study, Xenopus laevis tadpoles at stage 51 were exposed to fentin hydroxide and fenbutatin oxide (0.04, 0.20 and 1.00 μg·L-1) for 21 days. It was found that both compounds caused inhibitory effects on metamorphic development of tadpoles (e.g., significant decrease in hindlimb length and retarding development). Triiodothyronine (T3) significantly decreased in tadpoles exposed to 0.20 μg/L and 1.00 μg/L of the two OTPs for 14 days or 21 days. The expressions of TH responsive genes trβ, bteb and dio2 were down-regulated, while tshβ and slc5a5 were up-regulated. Surface plasmon resonance (SPR) binding assays showed that fentin hydroxide had a moderate affinity to recombinant human thyroid hormone receptor β but fenbutatin oxide did not have. Result of the SPR assay was highly consistent with the luciferase reporter gene assays that fentin hydroxide suppressed the relative luciferase activity in the presence of T3 while fenbutatin oxide did not, demonstrating fentin hydroxide but not fenbutatin oxide displayed an antagonistic activity against T3-TR complex mediated transcriptional activation. Overall, the findings elucidated the mechanisms induced by OTPs along HPT axis. These results highlighted the adverse influences of organotin pesticides on thyroid hormone- dependent development in vertebrates and the need for more comprehensive investigations of their potential ecological risks." @default.
• W2970830310 created "2019-09-05" @default.
• W2970830310 creator A5003910789 @default.
• W2970830310 creator A5012460069 @default.
• W2970830310 creator A5049701270 @default.
• W2970830310 creator A5058096961 @default.
• W2970830310 creator A5059102477 @default.
• W2970830310 creator A5069183335 @default.
• W2970830310 creator A5086442776 @default.
• W2970830310 date "2019-12-01" @default.
• W2970830310 modified "2023-10-13" @default.
• W2970830310 title "Disruptive effects of two organotin pesticides on the thyroid signaling pathway in Xenopus laevis during metamorphosis" @default.
• W2970830310 cites W1513569516 @default.
• W2970830310 cites W1963256408 @default.
• W2970830310 cites W1974287386 @default.
• W2970830310 cites W1986068446 @default.
• W2970830310 cites W2000262653 @default.
• W2970830310 cites W2003815900 @default.
• W2970830310 cites W2007141580 @default.
• W2970830310 cites W2008499884 @default.
• W2970830310 cites W2011395631 @default.
• W2970830310 cites W2011798749 @default.
• W2970830310 cites W2015612554 @default.
• W2970830310 cites W2020145772 @default.
• W2970830310 cites W2042163502 @default.
• W2970830310 cites W2063737179 @default.
• W2970830310 cites W2070908085 @default.
• W2970830310 cites W2091299496 @default.
• W2970830310 cites W2098299168 @default.
• W2970830310 cites W2107277218 @default.
• W2970830310 cites W2168464188 @default.
• W2970830310 cites W2276758372 @default.
• W2970830310 cites W2291759717 @default.
• W2970830310 cites W2294091013 @default.
• W2970830310 cites W2327790346 @default.
• W2970830310 cites W2332171581 @default.
• W2970830310 cites W2396552335 @default.
• W2970830310 cites W2411363873 @default.
• W2970830310 cites W2513039295 @default.
• W2970830310 cites W2514426629 @default.
• W2970830310 cites W2539832890 @default.
• W2970830310 cites W2587031089 @default.
• W2970830310 cites W2623666974 @default.
• W2970830310 cites W2741715948 @default.
• W2970830310 cites W2753048381 @default.
• W2970830310 cites W2791257948 @default.
• W2970830310 cites W2800757174 @default.
• W2970830310 doi "https://doi.org/10.1016/j.scitotenv.2019.134140" @default.
• W2970830310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31476497" @default.
• W2970830310 hasPublicationYear "2019" @default.
• W2970830310 type Work @default.
• W2970830310 sameAs 2970830310 @default.
• W2970830310 citedByCount "5" @default.
• W2970830310 countsByYear W29708303102020 @default.
• W2970830310 countsByYear W29708303102021 @default.
• W2970830310 countsByYear W29708303102023 @default.
• W2970830310 crossrefType "journal-article" @default.
• W2970830310 hasAuthorship W2970830310A5003910789 @default.
• W2970830310 hasAuthorship W2970830310A5012460069 @default.
• W2970830310 hasAuthorship W2970830310A5049701270 @default.
• W2970830310 hasAuthorship W2970830310A5058096961 @default.
• W2970830310 hasAuthorship W2970830310A5059102477 @default.
• W2970830310 hasAuthorship W2970830310A5069183335 @default.
• W2970830310 hasAuthorship W2970830310A5086442776 @default.
• W2970830310 hasConcept C104317684 @default.
• W2970830310 hasConcept C109115496 @default.
• W2970830310 hasConcept C126322002 @default.
• W2970830310 hasConcept C134018914 @default.
• W2970830310 hasConcept C170493617 @default.
• W2970830310 hasConcept C185592680 @default.
• W2970830310 hasConcept C2777886399 @default.
• W2970830310 hasConcept C2778288131 @default.
• W2970830310 hasConcept C2779535977 @default.
• W2970830310 hasConcept C526584372 @default.
• W2970830310 hasConcept C55493867 @default.
• W2970830310 hasConcept C71315377 @default.
• W2970830310 hasConcept C71924100 @default.
• W2970830310 hasConcept C86803240 @default.
• W2970830310 hasConceptScore W2970830310C104317684 @default.
• W2970830310 hasConceptScore W2970830310C109115496 @default.
• W2970830310 hasConceptScore W2970830310C126322002 @default.
• W2970830310 hasConceptScore W2970830310C134018914 @default.
• W2970830310 hasConceptScore W2970830310C170493617 @default.
• W2970830310 hasConceptScore W2970830310C185592680 @default.
• W2970830310 hasConceptScore W2970830310C2777886399 @default.
• W2970830310 hasConceptScore W2970830310C2778288131 @default.
• W2970830310 hasConceptScore W2970830310C2779535977 @default.
• W2970830310 hasConceptScore W2970830310C526584372 @default.
• W2970830310 hasConceptScore W2970830310C55493867 @default.
• W2970830310 hasConceptScore W2970830310C71315377 @default.
• W2970830310 hasConceptScore W2970830310C71924100 @default.
• W2970830310 hasConceptScore W2970830310C86803240 @default.
• W2970830310 hasFunder F4320321001 @default.
• W2970830310 hasFunder F4320321543 @default.
• W2970830310 hasFunder F4320338464 @default.
• W2970830310 hasLocation W29708303101 @default.
• W2970830310 hasLocation W29708303102 @default.
• W2970830310 hasOpenAccess W2970830310 @default.

• next