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• W2970854955 startingPage "294" @default.
• W2970854955 abstract "<h3>Background:</h3> Serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. The temporal lobe receives a high density of serotonergic afferent projections, and responses in the primary auditory cortex to sound are modulated by serotonergic tone. However, the associations between changes in serotonergic tone, disease state and changes in auditory cortical function remain to be clarified. <h3>Methods:</h3> We quantified serotonin 1A (5-HT_1A) receptor binding, serotonin 2A (5-HT_2A) receptor binding, and serotonin transporter (SERT) binding in Brodmann areas (BA) 41/42, 22, 9 and 4 from postmortem brain sections of 40 psychiatrically healthy controls and 39 individuals who had a history of a major depressive episode (MDE). <h3>Results:</h3> There was 33% lower 5-HT_2A receptor binding in BA 41/42 in individuals who had an MDE than in controls (<i>p</i> = 0.0069). Neither 5-HT_1A nor SERT binding in BA 41/42 differed between individuals who had an MDE and controls. We also found 14% higher 5-HT_1A receptor binding (<i>p</i> = 0.045) and 21% lower SERT binding in BA 9 of individuals who had an MDE (<i>p</i> = 0.045). <h3>Limitations:</h3> The study was limited by the small number of postmortem brain samples including BA 41/42 available for binding assays and the large overlap between suicide and depression in the MDE sample. <h3>Conclusion:</h3> Depression may be associated with altered serotonergic function in the auditory cortex involving the 5-HT_2A receptor and is part of a wider view of the pathophysiology of mood disorders extending beyond psychopathology." @default.
• W2970854955 created "2019-09-05" @default.
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• W2970854955 date "2019-09-01" @default.
• W2970854955 modified "2023-09-30" @default.
• W2970854955 title "5-HT_1A receptor, 5-HT_2A receptor and serotonin transporter binding in the human auditory cortex in depression" @default.
• W2970854955 cites W1522335173 @default.
• W2970854955 cites W1594455097 @default.
• W2970854955 cites W1899399637 @default.
• W2970854955 cites W1964200024 @default.
• W2970854955 cites W1964358239 @default.
• W2970854955 cites W1966253466 @default.
• W2970854955 cites W1967923543 @default.
• W2970854955 cites W1968884554 @default.
• W2970854955 cites W1971723831 @default.
• W2970854955 cites W1974105077 @default.
• W2970854955 cites W1974989163 @default.
• W2970854955 cites W1979743745 @default.
• W2970854955 cites W1993273089 @default.
• W2970854955 cites W1998644699 @default.
• W2970854955 cites W2002221330 @default.
• W2970854955 cites W2003833885 @default.
• W2970854955 cites W2011401495 @default.
• W2970854955 cites W2013029069 @default.
• W2970854955 cites W2015076008 @default.
• W2970854955 cites W2020062723 @default.
• W2970854955 cites W2022452437 @default.
• W2970854955 cites W2022455207 @default.
• W2970854955 cites W2022468859 @default.
• W2970854955 cites W2023225473 @default.
• W2970854955 cites W2028129568 @default.
• W2970854955 cites W2028524283 @default.
• W2970854955 cites W2028804705 @default.
• W2970854955 cites W2029794675 @default.
• W2970854955 cites W2030772288 @default.
• W2970854955 cites W2035163133 @default.
• W2970854955 cites W2036161709 @default.
• W2970854955 cites W2042966037 @default.
• W2970854955 cites W2045554054 @default.
• W2970854955 cites W2045811631 @default.
• W2970854955 cites W2046481066 @default.
• W2970854955 cites W2051423370 @default.
• W2970854955 cites W2052519442 @default.
• W2970854955 cites W2056674018 @default.
• W2970854955 cites W2057383836 @default.
• W2970854955 cites W2057532104 @default.
• W2970854955 cites W2059026752 @default.
• W2970854955 cites W2063495321 @default.
• W2970854955 cites W2068475798 @default.
• W2970854955 cites W2070575208 @default.
• W2970854955 cites W2072806123 @default.
• W2970854955 cites W2075327466 @default.
• W2970854955 cites W2075430022 @default.
• W2970854955 cites W2076804255 @default.
• W2970854955 cites W2081458788 @default.
• W2970854955 cites W2093956835 @default.
• W2970854955 cites W2099618371 @default.
• W2970854955 cites W2104084903 @default.
• W2970854955 cites W2107995274 @default.
• W2970854955 cites W2109991255 @default.
• W2970854955 cites W2114644502 @default.
• W2970854955 cites W2121068766 @default.
• W2970854955 cites W2121809100 @default.
• W2970854955 cites W2133789669 @default.
• W2970854955 cites W2143059906 @default.
• W2970854955 cites W2143591430 @default.
• W2970854955 cites W2144665117 @default.
• W2970854955 cites W2149665155 @default.
• W2970854955 cites W2151893492 @default.
• W2970854955 cites W2159545398 @default.
• W2970854955 cites W2161945182 @default.
• W2970854955 cites W2163686316 @default.
• W2970854955 cites W2192977314 @default.
• W2970854955 cites W2302121233 @default.
• W2970854955 cites W2414481828 @default.
• W2970854955 cites W2415110042 @default.
• W2970854955 cites W2553094875 @default.
• W2970854955 cites W2760207472 @default.
• W2970854955 cites W2776599407 @default.
• W2970854955 cites W2904112223 @default.
• W2970854955 doi "https://doi.org/10.1503/jpn.180190" @default.
• W2970854955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6710086" @default.
• W2970854955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31120232" @default.
• W2970854955 hasPublicationYear "2019" @default.
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