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- W2970905999 abstract "Ibuprofen was encapsulated into pH-sensitive hybrid nanocomposite using amine-modified bimodal mesopores silica (BMMs) as core and poly(methylacrylic acid) (PMAA) as the shell. The various characterizations showed that PMAA-coated shell played a pH-dependent “open–close” switch, and BMMs as a stored drug carrier. The high drug loading and pH-responsive release performances in vitro could be successfully monitored by SAXS techniques, demonstrating the evolution of mass fractal with surface roughness and structural irregularities. The release mechanism was proposed, showing a “diffusion-controlled” profile in both acidic and alkaline medium. Finally, the pharmacokinetics of released-IBU in mice through intravenous injection was preliminarily explored." @default.
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- W2970905999 date "2019-08-30" @default.
- W2970905999 modified "2023-09-27" @default.
- W2970905999 title "pH-sensitive controlled release <i>in vitro</i> and pharmacokinetics of ibuprofen from hybrid nanocomposite using amine-modified bimodal mesopores silica as core and poly(methylacrylic acid) as shell" @default.
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- W2970905999 doi "https://doi.org/10.1080/00914037.2019.1655747" @default.
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