Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970951657> ?p ?o ?g. }
- W2970951657 endingPage "1020" @default.
- W2970951657 startingPage "1020" @default.
- W2970951657 abstract "The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host's attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the plasma membrane characteristic of viral infection. Another is the expression of plasma membrane-associated proteins, so-called restriction factors, which inhibit enveloped virions directly. HIV-1 encodes two countermeasures to these host defenses: The membrane-associated accessory proteins Vpu and Nef. In addition to inhibiting cell-mediated immune-surveillance, Vpu and Nef counteract membrane-associated restriction factors. These include BST-2, which traps newly formed virions at the plasma membrane unless counteracted by Vpu, and SERINC5, which decreases the infectivity of virions unless counteracted by Nef. Here we review key features of these two antiviral proteins, and we review Vpu and Nef, which deplete them from the plasma membrane by co-opting specific cellular proteins and pathways of membrane trafficking and protein-degradation. We also discuss other plasma membrane proteins modulated by HIV-1, particularly CD4, which, if not opposed in infected cells by Vpu and Nef, inhibits viral infectivity and increases the sensitivity of the viral envelope glycoprotein to host immunity." @default.
- W2970951657 created "2019-09-05" @default.
- W2970951657 creator A5003808857 @default.
- W2970951657 creator A5009363956 @default.
- W2970951657 creator A5034732247 @default.
- W2970951657 creator A5058260819 @default.
- W2970951657 creator A5077602109 @default.
- W2970951657 creator A5081531938 @default.
- W2970951657 date "2019-09-02" @default.
- W2970951657 modified "2023-10-15" @default.
- W2970951657 title "Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins" @default.
- W2970951657 cites W1498574963 @default.
- W2970951657 cites W1504625876 @default.
- W2970951657 cites W1529498974 @default.
- W2970951657 cites W1545558337 @default.
- W2970951657 cites W1564649778 @default.
- W2970951657 cites W1571744798 @default.
- W2970951657 cites W1621734805 @default.
- W2970951657 cites W1625411473 @default.
- W2970951657 cites W1674854702 @default.
- W2970951657 cites W1738572554 @default.
- W2970951657 cites W1793297159 @default.
- W2970951657 cites W1802930479 @default.
- W2970951657 cites W1898326375 @default.
- W2970951657 cites W1907955033 @default.
- W2970951657 cites W1911317520 @default.
- W2970951657 cites W1933898011 @default.
- W2970951657 cites W1964422613 @default.
- W2970951657 cites W1965019797 @default.
- W2970951657 cites W1968140392 @default.
- W2970951657 cites W1971434113 @default.
- W2970951657 cites W1974053173 @default.
- W2970951657 cites W1974392304 @default.
- W2970951657 cites W1976212425 @default.
- W2970951657 cites W1976867329 @default.
- W2970951657 cites W1980192086 @default.
- W2970951657 cites W1981879850 @default.
- W2970951657 cites W1984875237 @default.
- W2970951657 cites W1986384364 @default.
- W2970951657 cites W1989035987 @default.
- W2970951657 cites W1990070794 @default.
- W2970951657 cites W1990719919 @default.
- W2970951657 cites W1992968802 @default.
- W2970951657 cites W1994473067 @default.
- W2970951657 cites W1996636273 @default.
- W2970951657 cites W1998048564 @default.
- W2970951657 cites W1999272522 @default.
- W2970951657 cites W2001412213 @default.
- W2970951657 cites W2001430278 @default.
- W2970951657 cites W2002904708 @default.
- W2970951657 cites W2005780220 @default.
- W2970951657 cites W2007922771 @default.
- W2970951657 cites W2008017865 @default.
- W2970951657 cites W2008923412 @default.
- W2970951657 cites W2010127459 @default.
- W2970951657 cites W2010458160 @default.
- W2970951657 cites W2010801310 @default.
- W2970951657 cites W2011490877 @default.
- W2970951657 cites W2014759070 @default.
- W2970951657 cites W2014818809 @default.
- W2970951657 cites W2016769675 @default.
- W2970951657 cites W2016913504 @default.
- W2970951657 cites W2017980922 @default.
- W2970951657 cites W2019770663 @default.
- W2970951657 cites W2021067210 @default.
- W2970951657 cites W2021885135 @default.
- W2970951657 cites W2024047895 @default.
- W2970951657 cites W2025830466 @default.
- W2970951657 cites W2026313243 @default.
- W2970951657 cites W2026318059 @default.
- W2970951657 cites W2027048169 @default.
- W2970951657 cites W2032204627 @default.
- W2970951657 cites W2033148154 @default.
- W2970951657 cites W2034568446 @default.
- W2970951657 cites W2035549114 @default.
- W2970951657 cites W2036161664 @default.
- W2970951657 cites W2036270340 @default.
- W2970951657 cites W2036374978 @default.
- W2970951657 cites W2038032067 @default.
- W2970951657 cites W2043597268 @default.
- W2970951657 cites W2045350802 @default.
- W2970951657 cites W2045877830 @default.
- W2970951657 cites W2047452261 @default.
- W2970951657 cites W2049314466 @default.
- W2970951657 cites W2049461480 @default.
- W2970951657 cites W2052122476 @default.
- W2970951657 cites W2056990259 @default.
- W2970951657 cites W2057388439 @default.
- W2970951657 cites W2058703375 @default.
- W2970951657 cites W2062611394 @default.
- W2970951657 cites W2067599049 @default.
- W2970951657 cites W2070615094 @default.
- W2970951657 cites W2074767175 @default.
- W2970951657 cites W2078786014 @default.
- W2970951657 cites W2086264258 @default.
- W2970951657 cites W2087413714 @default.
- W2970951657 cites W2088308807 @default.
- W2970951657 cites W2094442995 @default.