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• W2970952334 endingPage "107750" @default.
• W2970952334 startingPage "107750" @default.
• W2970952334 abstract "Since 1993, over 20 new anti-seizure drugs (ASDs) have been identified in well-established animal seizure and epilepsy models and subsequently demonstrated to be effective in double-blinded, placebo-controlled clinical trials in patients with focal onset seizures. All clinically-available ASDs on the market today are effective in at least one of only three preclinical seizure and epilepsy models: the acute maximal electroshock (MES), the acute subcutaneous pentylenetetrazol (scPTZ) test, or the kindled rodent with chronic evoked seizures. Thus, it reasons that preclinical ASD discovery does not need significant revision to successfully identify ASDs for the symptomatic treatment of epilepsy. Unfortunately, a significant need still persists for more efficacious and better tolerated ASDs. This is particularly true for those patients whose seizures remain drug resistant. This review will focus on the continued utility of the acute MES and scPTZ tests, as well as the kindled rodent for current and future ASD discovery. These are the only clinically validated rodent models to date and been heavily used in the search for novel and more efficacious ASDs. This is to say that promising ASDs have been brought to the clinic on the basis of efficacy in these particular seizure and epilepsy models alone. This review also discusses some of the inherent advantages and limitations of these models relative to existing and emerging preclinical models. It then offers insight into future efforts to develop a preclinical model that will advance a truly transformative therapy for the symptomatic treatment of difficult to treat focal onset epilepsy. This article is part of the special issue entitled 'New Epilepsy Therapies for the 21st Century - From Antiseizure Drugs to Prevention, Modification and Cure of Epilepsy'." @default.
• W2970952334 created "2019-09-05" @default.
• W2970952334 creator A5005402221 @default.
• W2970952334 creator A5088706930 @default.
• W2970952334 date "2020-05-01" @default.
• W2970952334 modified "2023-10-02" @default.
• W2970952334 title "Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening" @default.
• W2970952334 cites W1558419262 @default.
• W2970952334 cites W1584575938 @default.
• W2970952334 cites W1920696238 @default.
• W2970952334 cites W1966251521 @default.
• W2970952334 cites W1968212169 @default.
• W2970952334 cites W1968259409 @default.
• W2970952334 cites W1969349798 @default.
• W2970952334 cites W1970747055 @default.
• W2970952334 cites W1975316639 @default.
• W2970952334 cites W1976304880 @default.
• W2970952334 cites W1978824962 @default.
• W2970952334 cites W1980574125 @default.
• W2970952334 cites W1994869219 @default.
• W2970952334 cites W1996258496 @default.
• W2970952334 cites W2006516773 @default.
• W2970952334 cites W2009250221 @default.
• W2970952334 cites W2013917514 @default.
• W2970952334 cites W2019884656 @default.
• W2970952334 cites W2021334241 @default.
• W2970952334 cites W2022637923 @default.
• W2970952334 cites W2022919161 @default.
• W2970952334 cites W2030455873 @default.
• W2970952334 cites W2031700674 @default.
• W2970952334 cites W2032216760 @default.
• W2970952334 cites W2035401777 @default.
• W2970952334 cites W2036278822 @default.
• W2970952334 cites W2037641488 @default.
• W2970952334 cites W2039203321 @default.
• W2970952334 cites W2042152368 @default.
• W2970952334 cites W2045025689 @default.
• W2970952334 cites W2056098510 @default.
• W2970952334 cites W2057398613 @default.
• W2970952334 cites W2058979471 @default.
• W2970952334 cites W2059513822 @default.
• W2970952334 cites W2061473666 @default.
• W2970952334 cites W2063466487 @default.
• W2970952334 cites W2063788308 @default.
• W2970952334 cites W2067582627 @default.
• W2970952334 cites W2072738567 @default.
• W2970952334 cites W2077005987 @default.
• W2970952334 cites W2082765500 @default.
• W2970952334 cites W2084611794 @default.
• W2970952334 cites W2086659984 @default.
• W2970952334 cites W2092535327 @default.
• W2970952334 cites W2100283245 @default.
• W2970952334 cites W2126184619 @default.
• W2970952334 cites W2146793066 @default.
• W2970952334 cites W2149405816 @default.
• W2970952334 cites W2155633484 @default.
• W2970952334 cites W2161161622 @default.
• W2970952334 cites W2162587549 @default.
• W2970952334 cites W2164573587 @default.
• W2970952334 cites W2166727698 @default.
• W2970952334 cites W2291417222 @default.
• W2970952334 cites W2326652191 @default.
• W2970952334 cites W2326912412 @default.
• W2970952334 cites W2476169670 @default.
• W2970952334 cites W2476259579 @default.
• W2970952334 cites W2493372935 @default.
• W2970952334 cites W2530182352 @default.
• W2970952334 cites W2605176599 @default.
• W2970952334 cites W2609313476 @default.
• W2970952334 cites W2610432544 @default.
• W2970952334 cites W2625572971 @default.
• W2970952334 cites W2728610686 @default.
• W2970952334 cites W2761862301 @default.
• W2970952334 cites W2773092691 @default.
• W2970952334 cites W2777270043 @default.
• W2970952334 cites W2791893982 @default.
• W2970952334 cites W2794791794 @default.
• W2970952334 cites W2802489719 @default.
• W2970952334 cites W2890178711 @default.
• W2970952334 cites W2890417736 @default.
• W2970952334 cites W2913351543 @default.
• W2970952334 cites W2924912121 @default.
• W2970952334 cites W2949126889 @default.
• W2970952334 cites W2966060289 @default.
• W2970952334 cites W4242765791 @default.
• W2970952334 cites W4255729526 @default.
• W2970952334 cites W2515101127 @default.
• W2970952334 doi "https://doi.org/10.1016/j.neuropharm.2019.107750" @default.
• W2970952334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7470169" @default.
• W2970952334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31469995" @default.
• W2970952334 hasPublicationYear "2020" @default.
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