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- W2971018052 abstract "M. tuberculosis complex Uganda (MTBC-Ug)genotype is responsible for majority (68 %) of tuberculosis (TB) cases in peri-urban Kampala-Uganda, the reasons for this is unknown. In the current study we set out to understand why MTBC-Ug genotype is the main cause of tuberculosis.. Objectives To develop an assay that accurately identifies MTBC genotypes circulating in peri-urban Kampala To seek for TB patient characteristic that can be used to explain the dornimance Method Using MTBC lineage specific genetic markers we developed an assay that can accurately identifies MTBC, we used the assay to genotype 1746 MTBC isolates from adult patients enrolled in household study between (1992-2010) in peri-urban Kampala. The resultant data was used to seek for association between MTBC genotypes and patient clinical/demographic characteristics. Results The data showed 3 main MTBC genotypes circulating in peri-urban Kampala and none of these was associated with increased lung cavitation (holes in the lung) a measure of disease transmission (OR=1.08; CI at 95%= 0.78-1.51). However, smoking (OR=4.8; CI=3.33-6.84), cough with blood (OR=2; CI=1.10-2.42); low income (OR=2; CI=1.47-3.01) and HIV (OR=0.62; CI= 0.45-0.84) are risk factors for cavitary tuberculosis. Conclusion Three MTBC genotypes (lineages) circulating in peri-urban Kampala and none of these is associated with increased transmission" @default.
- W2971018052 created "2019-09-05" @default.
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- W2971018052 date "2019-08-05" @default.
- W2971018052 modified "2023-09-27" @default.
- W2971018052 title "Phenotypes of Mycobacterium tuberculosis complex Uganda family" @default.
- W2971018052 doi "https://doi.org/10.21955/aasopenres.1114908.1" @default.
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