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- W2971079908 endingPage "104439" @default.
- W2971079908 startingPage "104439" @default.
- W2971079908 abstract "The apoptosis alternate cell death pathways are extensively studied in recent years and their significance has been well recognized. With identification of newer cell death pathways, the therapeutic opportunities to modulate cell death have indeed further extended. Necroptosis, among other apoptosis alternate pathways, has been immensely studied recently in different hepatic disease models. Receptor-interacting protein 1 (RIPK1), RIPK3 and mixed lineage kinase domain like (MLKL) seemed to be the key players to mediate necroptosis pathway. Initially, necroptosis seemed to be following the typical pathway. But recently diverse pathways and outcomes have been observed. With recent studies reporting diverse outcomes, the necroptosis signalling has become a lot more interesting and intricate. The typical RIPK1 signalling followed by RIPK3 and MLKL might not always be strictly followed. Although, necroptosis signalling has been intensively investigated in various disease conditions; however, there is still a need to further elaborate and understand the unique scaffolding and kinase properties and other signalling interactions of necroptosis signalling molecules." @default.
- W2971079908 created "2019-09-05" @default.
- W2971079908 creator A5032284402 @default.
- W2971079908 creator A5041127618 @default.
- W2971079908 creator A5058376995 @default.
- W2971079908 creator A5073967981 @default.
- W2971079908 date "2019-10-01" @default.
- W2971079908 modified "2023-10-16" @default.
- W2971079908 title "Necroptosis signaling in liver diseases: An update" @default.
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