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- W2971116045 endingPage "115645" @default.
- W2971116045 startingPage "115645" @default.
- W2971116045 abstract "Long-term exposures to environmental toxicants are causative factors for human health effects. DNA damages are of great interest in that they can serve as the potential biomarkers of environmental exposure and mutations. Qualitative and quantitative detection of their level in genomic DNA, are helpful for the understanding of the generation, transformation, repair and fate of DNA damages and for elucidating the mechanism underlying carcinogenesis. Methodologies based on liquid chromatography-mass spectrometry (LC-MS) have shown unique advantages in accurate and highly sensitive analysis of these structurally modified DNA damages. The present review summarizes our current knowledge on LC-MS analysis of genetic DNA damages, with special emphasis on structurally chemical DNA modifications induced by environmental exposure. Advances in LC-MS analysis and monitoring of oxidative DNA lesion, DNA adducts induced by heavy metals, persistent organic pollutants, bisphenols, fine particulate matters, aldehydes and halobenzoquinones are comprehensively summarized." @default.
- W2971116045 created "2019-09-05" @default.
- W2971116045 creator A5008405013 @default.
- W2971116045 creator A5013186280 @default.
- W2971116045 creator A5054418515 @default.
- W2971116045 date "2019-11-01" @default.
- W2971116045 modified "2023-10-09" @default.
- W2971116045 title "Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure" @default.
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- W2971116045 doi "https://doi.org/10.1016/j.trac.2019.115645" @default.
- W2971116045 hasPublicationYear "2019" @default.
- W2971116045 type Work @default.