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• W2971173212 startingPage "4294" @default.
• W2971173212 abstract "Opioid addiction is a chronic and complex disease characterized by relapse and remission. In the past decade, the opioid epidemic or opioid crisis in the United States has raised public awareness. Methadone, buprenorphine, and naloxone have proven their effectiveness in treating addicted individuals, and each of them has different effects on different opioid receptors. Classic and molecular genetic research has provided valuable information and revealed the possible mechanism of individual differences in vulnerability for opioid addiction. The polygenic risk score based on the results of a genome-wide association study (GWAS) may be a promising tool to evaluate the association between phenotypes and genetic markers across the entire genome. A novel gene editing approach, clustered, regularly-interspaced short palindromic repeats (CRISPR), has been widely used in basic research and potentially applied to human therapeutics such as mental illness; many applications against addiction based on CRISPR are currently under research, and some are successful in animal studies. In this article, we summarized the biological mechanisms of opioid addiction and medical treatments, and we reviewed articles about the genetics of opioid addiction, the promising approach to predict the risk of opioid addiction, and a novel gene editing approach. Further research on medical treatments based on individual vulnerability is needed." @default.
• W2971173212 created "2019-09-05" @default.
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• W2971173212 date "2019-09-02" @default.
• W2971173212 modified "2023-10-14" @default.
• W2971173212 title "Opioid Addiction, Genetic Susceptibility, and Medical Treatments: A Review" @default.
• W2971173212 cites W1492294380 @default.
• W2971173212 cites W1527704975 @default.
• W2971173212 cites W1545782352 @default.
• W2971173212 cites W1549469986 @default.
• W2971173212 cites W1575576947 @default.
• W2971173212 cites W1839921965 @default.
• W2971173212 cites W1841881976 @default.
• W2971173212 cites W1963498395 @default.
• W2971173212 cites W1965405931 @default.
• W2971173212 cites W1968086599 @default.
• W2971173212 cites W1968999996 @default.
• W2971173212 cites W1978715208 @default.
• W2971173212 cites W1979031324 @default.
• W2971173212 cites W1979385488 @default.
• W2971173212 cites W1990139289 @default.
• W2971173212 cites W1992389336 @default.
• W2971173212 cites W1994814682 @default.
• W2971173212 cites W1997338841 @default.
• W2971173212 cites W2000492468 @default.
• W2971173212 cites W2003419870 @default.
• W2971173212 cites W2004206666 @default.
• W2971173212 cites W2008179914 @default.
• W2971173212 cites W2010427677 @default.
• W2971173212 cites W2010957828 @default.
• W2971173212 cites W2011645297 @default.
• W2971173212 cites W2012129255 @default.
• W2971173212 cites W2013376909 @default.
• W2971173212 cites W2021921399 @default.
• W2971173212 cites W2025339047 @default.
• W2971173212 cites W2025466447 @default.
• W2971173212 cites W2028836273 @default.
• W2971173212 cites W2030501710 @default.
• W2971173212 cites W2035863822 @default.
• W2971173212 cites W2038377187 @default.
• W2971173212 cites W2043575141 @default.
• W2971173212 cites W204395665 @default.
• W2971173212 cites W2046976164 @default.
• W2971173212 cites W2047320236 @default.
• W2971173212 cites W2047326145 @default.
• W2971173212 cites W2051812608 @default.
• W2971173212 cites W2053450543 @default.
• W2971173212 cites W2060501426 @default.
• W2971173212 cites W2063384087 @default.
• W2971173212 cites W2069491772 @default.
• W2971173212 cites W2073304132 @default.
• W2971173212 cites W2077736338 @default.
• W2971173212 cites W2079086643 @default.
• W2971173212 cites W2079553294 @default.
• W2971173212 cites W2079708017 @default.
• W2971173212 cites W2080709600 @default.
• W2971173212 cites W2081515697 @default.
• W2971173212 cites W2081812523 @default.
• W2971173212 cites W2083064925 @default.
• W2971173212 cites W2085790872 @default.
• W2971173212 cites W2086482649 @default.
• W2971173212 cites W2095048077 @default.
• W2971173212 cites W2097740330 @default.
• W2971173212 cites W2098380904 @default.
• W2971173212 cites W2098597355 @default.
• W2971173212 cites W2099814519 @default.
• W2971173212 cites W2102325625 @default.
• W2971173212 cites W2104930749 @default.
• W2971173212 cites W2106719141 @default.
• W2971173212 cites W2107343337 @default.
• W2971173212 cites W2110846909 @default.
• W2971173212 cites W2111666128 @default.
• W2971173212 cites W2112755003 @default.
• W2971173212 cites W2113754000 @default.
• W2971173212 cites W2116787219 @default.
• W2971173212 cites W2124484771 @default.
• W2971173212 cites W2126459367 @default.
• W2971173212 cites W2127673034 @default.
• W2971173212 cites W2129143684 @default.
• W2971173212 cites W2132468342 @default.
• W2971173212 cites W2132974770 @default.
• W2971173212 cites W2134012226 @default.
• W2971173212 cites W2134855335 @default.
• W2971173212 cites W2135159454 @default.
• W2971173212 cites W2145849285 @default.
• W2971173212 cites W2146443350 @default.
• W2971173212 cites W2147245308 @default.
• W2971173212 cites W2147528480 @default.
• W2971173212 cites W2153968413 @default.
• W2971173212 cites W2154246724 @default.
• W2971173212 cites W2161014456 @default.
• W2971173212 cites W2162097818 @default.
• W2971173212 cites W2162847155 @default.
• W2971173212 cites W2165387836 @default.
• W2971173212 cites W2168630917 @default.

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