Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971189076> ?p ?o ?g. }
- W2971189076 endingPage "798" @default.
- W2971189076 startingPage "790" @default.
- W2971189076 abstract "Beneficial effects of Korean Red Ginseng (KRG) on polycystic ovarian syndrome (PCOS) remains unclear.We examined whether pretreatment (daily from 2 hours before PCOS induction) with KRG extract in water (KRGE; 75 and 150 mg/kg/day, p.o.) could exert a favorable effect in a dehydroepiandrosterone (DHEA)-induced PCOS rat model.Pretreatment with KRGE significantly inhibited the elevation of body and ovary weights, the increase in number and size of ovarian cysts, and the elevation of serum testosterone and estradiol levels induced by DHEA. Pretreatment with KRGE also inhibited macrophage infiltration and enhanced mRNA expression levels of chemokines [interleukin (IL)-8, monocyte chemoattractant protein-1), proinflammatory cytokines (IL-1β, IL-6), and inducible nitric oxide synthase in ovaries induced by DHEA. It also prevented the reduction in mRNA expression of growth factors (epidermal growth factor, transforming growth factor-beta (EGF, TGF-β)) related to inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cell pathway and stimulation of the nuclear factor erythroid-derived 2-related factor 2 pathway. Interestingly, KRGE or representative ginsenosides (Rb1, Rg1, and Rg3(s)) inhibited the activity of inflammatory enzymes cyclooxygenase-2 and iNOS, cytosolic p-IkB, and nuclear p-nuclear factor kappa-light-chain-enhancer of activated B in lipopolysaccharide-induced RAW264.7 cells, whereas they increased nuclear factor erythroid-derived 2-related factor 2 nuclear translocation.These results provide that KRGE could prevent DHEA-induced PCOS via antiinflammatory and antioxidant activities. Thus, KRGE may be used in preventive and therapeutic strategies for PCOS-like symptoms." @default.
- W2971189076 created "2019-09-05" @default.
- W2971189076 creator A5001158987 @default.
- W2971189076 creator A5009159554 @default.
- W2971189076 creator A5033184461 @default.
- W2971189076 creator A5038956457 @default.
- W2971189076 creator A5043926214 @default.
- W2971189076 creator A5064077703 @default.
- W2971189076 creator A5065885242 @default.
- W2971189076 creator A5070294890 @default.
- W2971189076 creator A5074753836 @default.
- W2971189076 creator A5081210734 @default.
- W2971189076 creator A5082846946 @default.
- W2971189076 creator A5084665044 @default.
- W2971189076 creator A5085642896 @default.
- W2971189076 date "2020-11-01" @default.
- W2971189076 modified "2023-09-25" @default.
- W2971189076 title "Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its antiinflammatory and antioxidant activities" @default.
- W2971189076 cites W1539334271 @default.
- W2971189076 cites W1559960574 @default.
- W2971189076 cites W1897491882 @default.
- W2971189076 cites W1965264162 @default.
- W2971189076 cites W1970586482 @default.
- W2971189076 cites W1970780765 @default.
- W2971189076 cites W1973015402 @default.
- W2971189076 cites W1975110437 @default.
- W2971189076 cites W1976950210 @default.
- W2971189076 cites W1983866386 @default.
- W2971189076 cites W1988361540 @default.
- W2971189076 cites W1991615616 @default.
- W2971189076 cites W2006938411 @default.
- W2971189076 cites W2010325861 @default.
- W2971189076 cites W2018396104 @default.
- W2971189076 cites W2022818888 @default.
- W2971189076 cites W2032173003 @default.
- W2971189076 cites W2034054759 @default.
- W2971189076 cites W2046806616 @default.
- W2971189076 cites W2048738950 @default.
- W2971189076 cites W2048767113 @default.
- W2971189076 cites W2049363219 @default.
- W2971189076 cites W2054429955 @default.
- W2971189076 cites W2057313063 @default.
- W2971189076 cites W2060291227 @default.
- W2971189076 cites W2067095639 @default.
- W2971189076 cites W2073812530 @default.
- W2971189076 cites W2077717013 @default.
- W2971189076 cites W2083078677 @default.
- W2971189076 cites W2096224929 @default.
- W2971189076 cites W2104396651 @default.
- W2971189076 cites W2106543279 @default.
- W2971189076 cites W2107119205 @default.
- W2971189076 cites W2107277218 @default.
- W2971189076 cites W2107462690 @default.
- W2971189076 cites W2113159454 @default.
- W2971189076 cites W2114250093 @default.
- W2971189076 cites W2122313273 @default.
- W2971189076 cites W2122342236 @default.
- W2971189076 cites W2125167724 @default.
- W2971189076 cites W2135136722 @default.
- W2971189076 cites W2137314337 @default.
- W2971189076 cites W2137516955 @default.
- W2971189076 cites W2144280418 @default.
- W2971189076 cites W2147572545 @default.
- W2971189076 cites W2148233846 @default.
- W2971189076 cites W2154836031 @default.
- W2971189076 cites W2157268169 @default.
- W2971189076 cites W2161608856 @default.
- W2971189076 cites W2175990978 @default.
- W2971189076 cites W2176813897 @default.
- W2971189076 cites W2192080449 @default.
- W2971189076 cites W2287961968 @default.
- W2971189076 cites W2296320689 @default.
- W2971189076 cites W2398517584 @default.
- W2971189076 cites W2587750715 @default.
- W2971189076 cites W2606326475 @default.
- W2971189076 cites W2786867738 @default.
- W2971189076 cites W2902520313 @default.
- W2971189076 cites W2905721544 @default.
- W2971189076 cites W2980768966 @default.
- W2971189076 doi "https://doi.org/10.1016/j.jgr.2019.08.007" @default.
- W2971189076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7655494" @default.
- W2971189076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33192122" @default.
- W2971189076 hasPublicationYear "2020" @default.
- W2971189076 type Work @default.
- W2971189076 sameAs 2971189076 @default.
- W2971189076 citedByCount "18" @default.
- W2971189076 countsByYear W29711890762021 @default.
- W2971189076 countsByYear W29711890762022 @default.
- W2971189076 countsByYear W29711890762023 @default.
- W2971189076 crossrefType "journal-article" @default.
- W2971189076 hasAuthorship W2971189076A5001158987 @default.
- W2971189076 hasAuthorship W2971189076A5009159554 @default.
- W2971189076 hasAuthorship W2971189076A5033184461 @default.
- W2971189076 hasAuthorship W2971189076A5038956457 @default.
- W2971189076 hasAuthorship W2971189076A5043926214 @default.
- W2971189076 hasAuthorship W2971189076A5064077703 @default.
- W2971189076 hasAuthorship W2971189076A5065885242 @default.
- W2971189076 hasAuthorship W2971189076A5070294890 @default.