Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971202011> ?p ?o ?g. }
- W2971202011 abstract "Cytomegalovirus (CMV) is a leading cause of congenital disease in newborns, and an effective vaccine remains an elusive goal. The guinea pig is the only small-animal model for cCMV. Guinea pig cytomegalovirus (GPCMV) encodes a glycoprotein pentamer complex (PC) for entry into non-fibroblast cells, including placental trophoblasts, to enable cCMV. As with human cytomegalovirus (HCMV), GPCMV uses a specific cell receptor (PDGFRA) for fibroblast entry, but other receptors are required for non-fibroblast cells. A disabled infectious single-cycle (DISC) GPCMV vaccine strain induced an antibody immune response to the viral pentamer to enhance virus neutralization on non-fibroblast cells, and vaccinated animals were fully protected against cCMV. Inclusion of the PC as part of a vaccine design dramatically improved vaccine efficacy, and this finding underlines the importance of the immune response to the PC in contributing toward protection against cCMV. This vaccine represents an important milestone in the development of a vaccine against cCMV." @default.
- W2971202011 created "2019-09-05" @default.
- W2971202011 creator A5040920159 @default.
- W2971202011 creator A5063110297 @default.
- W2971202011 creator A5090234467 @default.
- W2971202011 date "2019-11-15" @default.
- W2971202011 modified "2023-09-24" @default.
- W2971202011 title "Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model" @default.
- W2971202011 cites W1526716679 @default.
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- W2971202011 cites W1550766309 @default.
- W2971202011 cites W1558169244 @default.
- W2971202011 cites W1781401434 @default.
- W2971202011 cites W1785628209 @default.
- W2971202011 cites W1837498928 @default.
- W2971202011 cites W1962159422 @default.
- W2971202011 cites W1965971941 @default.
- W2971202011 cites W1971720261 @default.
- W2971202011 cites W1971742580 @default.
- W2971202011 cites W1973708619 @default.
- W2971202011 cites W1974646273 @default.
- W2971202011 cites W1981537524 @default.
- W2971202011 cites W1982130038 @default.
- W2971202011 cites W1988863963 @default.
- W2971202011 cites W1995563332 @default.
- W2971202011 cites W1996573297 @default.
- W2971202011 cites W2002488216 @default.
- W2971202011 cites W2012102254 @default.
- W2971202011 cites W2012620287 @default.
- W2971202011 cites W2019117511 @default.
- W2971202011 cites W2024510213 @default.
- W2971202011 cites W2030246672 @default.
- W2971202011 cites W2032096903 @default.
- W2971202011 cites W2041799491 @default.
- W2971202011 cites W2043892364 @default.
- W2971202011 cites W2045091800 @default.
- W2971202011 cites W2045906773 @default.
- W2971202011 cites W2054515639 @default.
- W2971202011 cites W2056309685 @default.
- W2971202011 cites W2068787010 @default.
- W2971202011 cites W2074360461 @default.
- W2971202011 cites W2082222365 @default.
- W2971202011 cites W2085280361 @default.
- W2971202011 cites W2092665836 @default.
- W2971202011 cites W2092890929 @default.
- W2971202011 cites W2098834342 @default.
- W2971202011 cites W2103212167 @default.
- W2971202011 cites W2104280132 @default.
- W2971202011 cites W2108640614 @default.
- W2971202011 cites W2117068105 @default.
- W2971202011 cites W2118633863 @default.
- W2971202011 cites W2120154091 @default.
- W2971202011 cites W2133080844 @default.
- W2971202011 cites W2135318828 @default.
- W2971202011 cites W2142161841 @default.
- W2971202011 cites W2144625807 @default.
- W2971202011 cites W2154686122 @default.
- W2971202011 cites W2155955448 @default.
- W2971202011 cites W2160245647 @default.
- W2971202011 cites W2162778062 @default.
- W2971202011 cites W2164350818 @default.
- W2971202011 cites W2166789299 @default.
- W2971202011 cites W2295928395 @default.
- W2971202011 cites W2322964415 @default.
- W2971202011 cites W2336726944 @default.
- W2971202011 cites W2463416845 @default.
- W2971202011 cites W2465813018 @default.
- W2971202011 cites W2471390345 @default.
- W2971202011 cites W2539968206 @default.
- W2971202011 cites W2540531648 @default.
- W2971202011 cites W2562505728 @default.
- W2971202011 cites W2571705548 @default.
- W2971202011 cites W2587571177 @default.
- W2971202011 cites W2607301782 @default.
- W2971202011 cites W2666621883 @default.
- W2971202011 cites W2732927618 @default.
- W2971202011 cites W2734088619 @default.
- W2971202011 cites W2737649394 @default.
- W2971202011 cites W2750396658 @default.
- W2971202011 cites W2752680591 @default.
- W2971202011 cites W2787003107 @default.
- W2971202011 cites W2883530068 @default.
- W2971202011 cites W2887736433 @default.
- W2971202011 cites W2894937742 @default.
- W2971202011 cites W2913929538 @default.
- W2971202011 cites W2951644607 @default.
- W2971202011 cites W750660743 @default.
- W2971202011 cites W3121290646 @default.
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- W2971202011 doi "https://doi.org/10.1128/jvi.01442-19" @default.
- W2971202011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6819920" @default.
- W2971202011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31484753" @default.
- W2971202011 hasPublicationYear "2019" @default.
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