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- W2971300664 abstract "This manuscript aimed to investigate linc-PINT's role as a tumor suppressor and its downstream microRNAs (miRNAs) in esophageal cancer. Log-rank, Cox, and nomogram were used for survival analysis. Quantitative real-time polymerase chain reaction was used to evaluate the expression. Cell counting kit-8 was used for proliferation tests. As for in vivo experiments, low expression of linc-PINT was associated with better prognosis; besides, the nomogram indicated that linc-PINT, miR-543, and miR-576-5p served well in predicting the survival rate. As for the in vitro experiments, linc-PINT could directly regulate miR-543 and miR-576-5p to inhibit the proliferation of Eca-109 cell line. In conclusion, linc-PINT–miR-543/miR-576-5p pathway could predict the prognosis and provide novel therapeutic targets for esophageal cancer." @default.
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- W2971300664 date "2019-08-28" @default.
- W2971300664 modified "2023-09-22" @default.
- W2971300664 title "Linc‐PINT acted as a tumor suppressor by sponging miR‐543 and miR‐576‐5p in esophageal cancer" @default.
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- W2971300664 doi "https://doi.org/10.1002/jcb.28699" @default.
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