FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971307044> ?p ?o ?g. }

• W2971307044 endingPage "10533" @default.
• W2971307044 startingPage "10521" @default.
• W2971307044 abstract "This work was designed to comparatively investigate 27 dietary flavonoids that act as α-glucosidase inhibitors and insulin sensitizers. On the basis of the results of an in vitro experiment of α-glucosidase inhibition, myricetin (IC50 = 11.63 ± 0.36 μM) possessed the strongest inhibitory effect, followed by apigenin-7-O-glucoside (IC50 = 22.80 ± 0.24 μM) and fisetin (IC50 = 46.39 ± 0.34 μM). A three-dimensional quantitative structure-activity relationship model of α-glucosidase inhibitors with good predictive capability [comparative molecular field analysis, q2 = 0.529, optimum number of components (ONC) = 10, R2 = 0.996, F = 250.843, standard error of estimation (SEE) = 0.064, and two descriptors; comparative similarity index analysis, q2 = 0.515, ONC = 10, R2 = 0.997, F = 348.301, SEE = 0.054, and four descriptors] was established and indicated that meta positions of ring B favored bulky and minor, electron-withdrawing, and hydrogen bond donor groups. The presence of electron-donating and hydrogen bond acceptor groups at position 4' of ring B could improve α-glucosidase activity. Position 3 of ring C favored minor, electron-donating, and hydrogen bond donor groups, whereas position 7 of ring A favored bulky and hydrogen bond acceptor groups. Molecular docking screened five flavonoids (baicalein, isorhamnetin-3-O-rutinoside, apigenin-7-O-glucoside, kaempferol-7-O-β-glucoside, and cyanidin-3-O-glucoside) that can act as insulin sensitizers and form strong combinations with four key protein targets involved in the insulin signaling pathway. Apigenin-7-O-glucoside (60 μM) can effectively improve insulin resistance, and glucose uptake increased by approximately 73.06% relative to the model group of insulin-resistant HepG2 cells. Therefore, apigenin-7-O-glucoside might serve as the most effective α-glucosidase inhibitor and insulin sensitizer. This work may guide diabetes patients to improve their condition through dietary therapy." @default.
• W2971307044 created "2019-09-05" @default.
• W2971307044 creator A5007017016 @default.
• W2971307044 creator A5045019601 @default.
• W2971307044 creator A5063300708 @default.
• W2971307044 creator A5069347563 @default.
• W2971307044 creator A5088092816 @default.
• W2971307044 date "2019-08-28" @default.
• W2971307044 modified "2023-10-18" @default.
• W2971307044 title "Comparative Study of Dietary Flavonoids with Different Structures as α-Glucosidase Inhibitors and Insulin Sensitizers" @default.
• W2971307044 cites W1977157150 @default.
• W2971307044 cites W2019911715 @default.
• W2971307044 cites W2023163024 @default.
• W2971307044 cites W2023382320 @default.
• W2971307044 cites W2030467598 @default.
• W2971307044 cites W2041657200 @default.
• W2971307044 cites W2051756849 @default.
• W2971307044 cites W2076913768 @default.
• W2971307044 cites W2082998114 @default.
• W2971307044 cites W2087179001 @default.
• W2971307044 cites W2094398840 @default.
• W2971307044 cites W2096691315 @default.
• W2971307044 cites W2104676838 @default.
• W2971307044 cites W2111325549 @default.
• W2971307044 cites W2164430911 @default.
• W2971307044 cites W2164461312 @default.
• W2971307044 cites W2187119809 @default.
• W2971307044 cites W2342374551 @default.
• W2971307044 cites W2342778169 @default.
• W2971307044 cites W2365322978 @default.
• W2971307044 cites W2460877694 @default.
• W2971307044 cites W2527960632 @default.
• W2971307044 cites W2543931110 @default.
• W2971307044 cites W2551567866 @default.
• W2971307044 cites W2562526835 @default.
• W2971307044 cites W2587253709 @default.
• W2971307044 cites W2607033358 @default.
• W2971307044 cites W2624427760 @default.
• W2971307044 cites W2717915063 @default.
• W2971307044 cites W2751717006 @default.
• W2971307044 cites W2754094390 @default.
• W2971307044 cites W2783553641 @default.
• W2971307044 cites W2789884447 @default.
• W2971307044 cites W2800733835 @default.
• W2971307044 cites W2802005930 @default.
• W2971307044 cites W2802611761 @default.
• W2971307044 cites W2891428104 @default.
• W2971307044 cites W2903864994 @default.
• W2971307044 cites W2925965377 @default.
• W2971307044 cites W2950171690 @default.
• W2971307044 doi "https://doi.org/10.1021/acs.jafc.9b04943" @default.
• W2971307044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31461284" @default.
• W2971307044 hasPublicationYear "2019" @default.
• W2971307044 type Work @default.
• W2971307044 sameAs 2971307044 @default.
• W2971307044 citedByCount "55" @default.
• W2971307044 countsByYear W29713070442020 @default.
• W2971307044 countsByYear W29713070442021 @default.
• W2971307044 countsByYear W29713070442022 @default.
• W2971307044 countsByYear W29713070442023 @default.
• W2971307044 crossrefType "journal-article" @default.
• W2971307044 hasAuthorship W2971307044A5007017016 @default.
• W2971307044 hasAuthorship W2971307044A5045019601 @default.
• W2971307044 hasAuthorship W2971307044A5063300708 @default.
• W2971307044 hasAuthorship W2971307044A5069347563 @default.
• W2971307044 hasAuthorship W2971307044A5088092816 @default.
• W2971307044 hasConcept C112887158 @default.
• W2971307044 hasConcept C178790620 @default.
• W2971307044 hasConcept C185592680 @default.
• W2971307044 hasConcept C2778004101 @default.
• W2971307044 hasConcept C2778609962 @default.
• W2971307044 hasConcept C2779054382 @default.
• W2971307044 hasConcept C32909587 @default.
• W2971307044 hasConcept C55493867 @default.
• W2971307044 hasConcept C71240020 @default.
• W2971307044 hasConceptScore W2971307044C112887158 @default.
• W2971307044 hasConceptScore W2971307044C178790620 @default.
• W2971307044 hasConceptScore W2971307044C185592680 @default.
• W2971307044 hasConceptScore W2971307044C2778004101 @default.
• W2971307044 hasConceptScore W2971307044C2778609962 @default.
• W2971307044 hasConceptScore W2971307044C2779054382 @default.
• W2971307044 hasConceptScore W2971307044C32909587 @default.
• W2971307044 hasConceptScore W2971307044C55493867 @default.
• W2971307044 hasConceptScore W2971307044C71240020 @default.
• W2971307044 hasFunder F4320321001 @default.
• W2971307044 hasFunder F4320324174 @default.
• W2971307044 hasIssue "37" @default.
• W2971307044 hasLocation W29713070441 @default.
• W2971307044 hasLocation W29713070442 @default.
• W2971307044 hasOpenAccess W2971307044 @default.
• W2971307044 hasPrimaryLocation W29713070441 @default.
• W2971307044 hasRelatedWork W2015830670 @default.
• W2971307044 hasRelatedWork W2034135491 @default.
• W2971307044 hasRelatedWork W2046624244 @default.
• W2971307044 hasRelatedWork W2048515283 @default.
• W2971307044 hasRelatedWork W2125943300 @default.
• W2971307044 hasRelatedWork W2765596630 @default.
• W2971307044 hasRelatedWork W2908786751 @default.

• next