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- W2971311218 abstract "An estimated 10% of people over 65 years of age, and 30% of people over 85 years of age, have dementia. Dementia is the second leading cause of death in Australia, and is the single greatest cause of disability in Australians older than 65 years of age. These numbers are expected to only increase with the ageing population. While there are many different forms of dementia, Alzheimer’s disease is the most common – accounting for 70% of people with dementia. Alzheimer’s disease is a neurodegenerative condition and does not have a cure. It is characterised by ‘β-amyloid plaques’ found outside of brain cells, thought to impair brain synapses, and ‘tangles’ inside brain cells, thought to impair metabolic processes – causing cholinergic neuron destruction and low levels of acetylcholine. Anticholinesterases such as donepezil, galantamine or rivastigmine reduce the apparent cholinergic deficiency by reducing the breakdown of acetylcholine. As Alzheimer’s disease is also thought to be associated with glutamate excess, an N-methyl-D-aspartate (NMDA) antagonist – memantine – which may reduce glutamate-induced neuronal degeneration may be used. However, existing pharmacological management is limited in its effectiveness in reducing symptoms and improving quality of life, and does not slow the progression of the condition. The recent spate of failed clinical trials with new medicines intended to target these plaques and tangles has led to questions around the fundamental understanding of the pathophysiology behind Alzheimer’s disease. Therefore, the race is still on to find an effective pharmacological option." @default.
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- W2971311218 date "2019-01-01" @default.
- W2971311218 modified "2023-09-23" @default.
- W2971311218 title "SSRIs for mild cognitive impairment to Alzheimer's disease" @default.
- W2971311218 hasPublicationYear "2019" @default.
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