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• W2971312191 abstract "Decreased nitric oxide (NO) bioavailability and hydrogen sulfide (H2S) deficiency have been linked with the pathophysiology of type 2 diabetes (T2D). Restoration of NO levels by nitrite have been associated with favorable metabolic effects in T2D. Moreover, H2S can potentiate the effects of NO in the cardiovascular system. The aim of this study was to determine the effects of long-term co-administration of sodium nitrite and sodium hydrosulfide (NaSH) on carbohydrate metabolism in type 2 diabetic rats.T2D was induced using chronic high fat diet (HFD) feeding combined with low dose streptozotocin (STZ) regimen. Rats were divided into 5 groups (N = 10/group): Control, T2D, T2D + nitrite, T2D + NaSH, and T2D + nitrite + NaSH. Nitrite (50 mg/L in drinking water) and NaSH (0.28 mg/kg, daily i. p. injection) were administered for 9 weeks. Fasting serum glucose, insulin, lipid profile, liver function tests, and oxidative stress indices were measured. Intraperitoneal glucose tolerance test (GTT) was performed at the end of the eighth week, and three days later, intraperitoneal pyruvate tolerance test (PTT) was done. Protein levels and mRNA expression of glucose transporter type 4 (GLUT4) in soleus muscle and epididymal adipose tissue as well as mRNA expression of H2S-producing enzymes in the liver, soleus muscle, and epididymal adipose tissue were measured at the end of the study.Compared to the controls, HFD and STZ treated rats developed metabolic dysfunction. Nitrite treatment improved carbohydrate metabolism, liver function, and oxidative stress indices whereas NaSH treatment per se had no significant effects. However, co-administration of NaSH and nitrite resulted in further improvement in serum insulin level, GTT, PTT, liver function, oxidative stress, protein level and mRNA expression of GLUT4, as well as mRNA expression of H2S-producing enzymes in diabetic rats.Low dose of NaSH per se had no effect on carbohydrate metabolism while it potentiated the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats. These favorable effects were associated with decreased oxidative stress and increased GLUT4 expression in insulin-sensitive tissues as well as improvement of liver function." @default.
• W2971312191 created "2019-09-05" @default.
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• W2971312191 date "2019-11-01" @default.
• W2971312191 modified "2023-10-15" @default.
• W2971312191 title "Hydrogen sulfide potentiates the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats" @default.
• W2971312191 cites W1487411552 @default.
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• W2971312191 cites W1849276450 @default.
• W2971312191 cites W1965178433 @default.
• W2971312191 cites W1965318110 @default.
• W2971312191 cites W1969750765 @default.
• W2971312191 cites W1971447092 @default.
• W2971312191 cites W1971483431 @default.
• W2971312191 cites W1974484729 @default.
• W2971312191 cites W1979710206 @default.
• W2971312191 cites W1983524790 @default.
• W2971312191 cites W1988525521 @default.
• W2971312191 cites W1990308559 @default.
• W2971312191 cites W1992149051 @default.
• W2971312191 cites W1992890855 @default.
• W2971312191 cites W1995271247 @default.
• W2971312191 cites W1998026793 @default.
• W2971312191 cites W1999619247 @default.
• W2971312191 cites W2004580431 @default.
• W2971312191 cites W2009014858 @default.
• W2971312191 cites W2012081068 @default.
• W2971312191 cites W2012651694 @default.
• W2971312191 cites W2013901475 @default.
• W2971312191 cites W2015407072 @default.
• W2971312191 cites W2023004136 @default.
• W2971312191 cites W2031227342 @default.
• W2971312191 cites W2043132068 @default.
• W2971312191 cites W2048391225 @default.
• W2971312191 cites W2049215298 @default.
• W2971312191 cites W2057319083 @default.
• W2971312191 cites W2058839725 @default.
• W2971312191 cites W2063576996 @default.
• W2971312191 cites W2065063113 @default.
• W2971312191 cites W2074172668 @default.
• W2971312191 cites W2081447694 @default.
• W2971312191 cites W2091609695 @default.
• W2971312191 cites W2098453482 @default.
• W2971312191 cites W2104564480 @default.
• W2971312191 cites W2115415582 @default.
• W2971312191 cites W2126646026 @default.
• W2971312191 cites W2134850908 @default.
• W2971312191 cites W2152816919 @default.
• W2971312191 cites W2153365782 @default.
• W2971312191 cites W2161989576 @default.
• W2971312191 cites W2166680909 @default.
• W2971312191 cites W2172212184 @default.
• W2971312191 cites W2312383808 @default.
• W2971312191 cites W2336492617 @default.
• W2971312191 cites W2522874415 @default.
• W2971312191 cites W2532544513 @default.
• W2971312191 cites W2544091589 @default.
• W2971312191 cites W2565597194 @default.
• W2971312191 cites W2569498866 @default.
• W2971312191 cites W2584641688 @default.
• W2971312191 cites W2590952894 @default.
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• W2971312191 doi "https://doi.org/10.1016/j.niox.2019.08.006" @default.
• W2971312191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31479766" @default.
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