Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971319311> ?p ?o ?g. }
- W2971319311 endingPage "111642" @default.
- W2971319311 startingPage "111642" @default.
- W2971319311 abstract "By exploiting the power of multicomponent chemistry, a relatively small, diverse set of primary sulfonamides was synthesized and screened against a panel of human carbonic anhydrases to reveal a low-nanomolar, albeit non-selective hCA IV lead inhibitor. Investigation of the docking poses of this compound identified a hydrophilic pocket unique to hCA IV and conveniently positioned near the carboxylate functionality of the initial lead. Various residues capable of forming hydrogen bonds as well as salt bridges were placed in this pocket via a carboxamides linkage, which led to drastic improvement of potency and selectivity towards hCA IV. This improvement of the desired inhibitory profile was rationalized by the new contacts as had been envisioned. These new tool compounds were shown to possess selective, dose-dependent cytotoxicity against human glioma T98G cell line. The latter showed a substantially increased hCA IV mRNA expression under hypoxic conditions." @default.
- W2971319311 created "2019-09-05" @default.
- W2971319311 creator A5003204299 @default.
- W2971319311 creator A5018378636 @default.
- W2971319311 creator A5037870901 @default.
- W2971319311 creator A5049341154 @default.
- W2971319311 creator A5049458503 @default.
- W2971319311 creator A5072675383 @default.
- W2971319311 creator A5073129203 @default.
- W2971319311 creator A5086790197 @default.
- W2971319311 date "2019-11-01" @default.
- W2971319311 modified "2023-09-28" @default.
- W2971319311 title "From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction" @default.
- W2971319311 cites W1500036797 @default.
- W2971319311 cites W1573899446 @default.
- W2971319311 cites W1651958095 @default.
- W2971319311 cites W176484652 @default.
- W2971319311 cites W1886003831 @default.
- W2971319311 cites W1967169851 @default.
- W2971319311 cites W1972547175 @default.
- W2971319311 cites W1973135750 @default.
- W2971319311 cites W1975579638 @default.
- W2971319311 cites W1984698293 @default.
- W2971319311 cites W1989302836 @default.
- W2971319311 cites W2004759191 @default.
- W2971319311 cites W2005576554 @default.
- W2971319311 cites W2006175671 @default.
- W2971319311 cites W2011950726 @default.
- W2971319311 cites W2029584153 @default.
- W2971319311 cites W2047178318 @default.
- W2971319311 cites W2047393488 @default.
- W2971319311 cites W2054162695 @default.
- W2971319311 cites W2055064998 @default.
- W2971319311 cites W2068210639 @default.
- W2971319311 cites W2068987819 @default.
- W2971319311 cites W2079310958 @default.
- W2971319311 cites W2086902544 @default.
- W2971319311 cites W2087736720 @default.
- W2971319311 cites W2091379422 @default.
- W2971319311 cites W2095719702 @default.
- W2971319311 cites W2107473349 @default.
- W2971319311 cites W2113099054 @default.
- W2971319311 cites W2114809965 @default.
- W2971319311 cites W2114843025 @default.
- W2971319311 cites W2122257118 @default.
- W2971319311 cites W2149441684 @default.
- W2971319311 cites W2384255035 @default.
- W2971319311 cites W2393616893 @default.
- W2971319311 cites W2471456962 @default.
- W2971319311 cites W2509084281 @default.
- W2971319311 cites W2544282990 @default.
- W2971319311 cites W2549528988 @default.
- W2971319311 cites W2587107246 @default.
- W2971319311 cites W2588869820 @default.
- W2971319311 cites W2595910272 @default.
- W2971319311 cites W2604420724 @default.
- W2971319311 cites W2735939980 @default.
- W2971319311 cites W2737525571 @default.
- W2971319311 cites W2749613778 @default.
- W2971319311 cites W2754564069 @default.
- W2971319311 cites W2765470831 @default.
- W2971319311 cites W2768136027 @default.
- W2971319311 cites W2790127751 @default.
- W2971319311 cites W2793549061 @default.
- W2971319311 cites W2797930460 @default.
- W2971319311 cites W2801556832 @default.
- W2971319311 cites W2802505506 @default.
- W2971319311 cites W2885966831 @default.
- W2971319311 cites W2891768838 @default.
- W2971319311 cites W2900483416 @default.
- W2971319311 cites W2901679478 @default.
- W2971319311 cites W2902285912 @default.
- W2971319311 cites W2916876648 @default.
- W2971319311 cites W793656391 @default.
- W2971319311 doi "https://doi.org/10.1016/j.ejmech.2019.111642" @default.
- W2971319311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31476557" @default.
- W2971319311 hasPublicationYear "2019" @default.
- W2971319311 type Work @default.
- W2971319311 sameAs 2971319311 @default.
- W2971319311 citedByCount "10" @default.
- W2971319311 countsByYear W29713193112020 @default.
- W2971319311 countsByYear W29713193112021 @default.
- W2971319311 countsByYear W29713193112022 @default.
- W2971319311 countsByYear W29713193112023 @default.
- W2971319311 crossrefType "journal-article" @default.
- W2971319311 hasAuthorship W2971319311A5003204299 @default.
- W2971319311 hasAuthorship W2971319311A5018378636 @default.
- W2971319311 hasAuthorship W2971319311A5037870901 @default.
- W2971319311 hasAuthorship W2971319311A5049341154 @default.
- W2971319311 hasAuthorship W2971319311A5049458503 @default.
- W2971319311 hasAuthorship W2971319311A5072675383 @default.
- W2971319311 hasAuthorship W2971319311A5073129203 @default.
- W2971319311 hasAuthorship W2971319311A5086790197 @default.
- W2971319311 hasBestOaLocation W29713193112 @default.
- W2971319311 hasConcept C109316439 @default.
- W2971319311 hasConcept C112887158 @default.
- W2971319311 hasConcept C114373084 @default.
- W2971319311 hasConcept C118792377 @default.