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• W2971320072 abstract "Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade: CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)Journal of Biological ChemistryVol. 286Issue 29PreviewDiverse stimuli can feed into the MAPK/ERK cascade; this includes receptor tyrosine kinases, G protein-coupled receptors, integrins, and scavenger receptors (LDL receptor-related protein (LRP)). Here, we investigated the consequence of concomitant occupancy of the receptor tyrosine kinases (by EGF, basic FGF, VEGF, etc.) and of LRP family members (by LDL or lactoferrin). The simultaneous stimulation of a receptor tyrosine kinase by its cognate ligand and of LRP-1 (by lactoferrin or LDL) resulted in sustained activation of ERK, which was redirected to the cytoplasm. Full-Text PDF Open Access VOLUME 286 (2011) PAGES 25663–25674 This article has been withdrawn by Nishamol Geetha, Judit Mihaly, Alexander Stockenhuber, Francesco Blasi, Pavel Uhrin, Michael Freissmuth, and Johannes M. Breuss. The withdrawing authors regret that Bernd R. Binder passed away. In Fig. 3A, The EGF/LF lanes did not accurately represent the experimental results. The tERK lanes were duplicated in Fig. 3C. The LF lanes were derived from a different immunoblot in Fig. 3D. The pERK and tERK immunoblots from PDGF/LF treatment in Fig. 4B were reused in Fig. 4C for EGF/LF treatment. The DUSP1 and actin immunoblots from untreated cells in Fig. 7A were reused in Fig. 8C. The DUSP6 immunoblot from untreated cells in Fig. 7B was reused in Fig. 8D. In addition, the actin immunoblot from untreated cells in Fig. 7B was reused in Figs. 7C and 8D for the untreated samples. The corrected blots are available upon request." @default.
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• W2971320072 date "2019-08-01" @default.
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• W2971320072 title "Withdrawal: Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: Concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosphatases (DUSP1 and -6)." @default.
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