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- W2971323032 endingPage "1166" @default.
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- W2971323032 abstract "Aminoglycosides, a class of antibiotics that includes gentamicin, kanamycin, neomycin, streptomycin, tobramycin and apramycin, are derived from various streptomyces species. Despite the significant increase in the antibacterial resistant pathogens, aminoglycosides remain an important class of antimicrobial drugs due to their unique chemical structure which offers a broad spectrum of activity. The modification of antibiotics and their subsequent use in supramolecular chemistry is rarely reported. Given the importance of aminoglycosides, here we give a brief overview on the modification of 4,5- and 4,6-disubstituted deoxystreptamine classes of aminoglycosides through supramolecular chemistry and their potential for real world applications. We also make the case that the work in this area is gaining momentum, and there are significant opportunities to meet the challenges of modern antibiotics through the modification of aminoglycosides by harnessing the advantages of supramolecular chemistry." @default.
- W2971323032 created "2019-09-05" @default.
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- W2971323032 creator A5078904793 @default.
- W2971323032 creator A5091328368 @default.
- W2971323032 date "2019-08-26" @default.
- W2971323032 modified "2023-10-14" @default.
- W2971323032 title "The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications" @default.
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- W2971323032 doi "https://doi.org/10.1002/open.201900193" @default.
- W2971323032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6718072" @default.
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- W2971323032 hasPublicationYear "2019" @default.
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