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• W2971323430 endingPage "e7626" @default.
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• W2971323430 abstract "Phytophthora capsica is a destructive oomycete plant pathogen that causes huge losses to crop production worldwide. However, the novel fungicide SYP-14288 has shown excellent activity against various stages of the oomycete life cycle as well against fungal plant pathogens. The current study utilized isobaric tags for relative and absolute quantitation technology to generate proteome profiles of P. capsici in the presence or absence of SYP-14288 in order to gain a greater understanding of the SYP-14288 mode of action. A total of 1,443 individual proteins were identified during the investigation, of which 599 were considered to have significantly altered expression. Further investigation using Cluster of Orthologous Groups of proteins analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated most of the proteins with altered expression were associated with carbohydrate metabolism, energy metabolism and their downstream biological functions, especially with regard to oxidoreductase activity and subsequent adenosine triphosphate (ATP) production associated pathways. Quantitative expression analysis using qRT-PCR validated the proteomic data. These results seem to indicate that SYP-14288 treatment caused a shift in energy metabolism that resulted in the activation of compensatory mechanisms affecting carbohydrate and lipid metabolism. The study also found evidence that the up-regulation of transmembrane transporters and proteins associated with stress response might also be coopted to compensate for the disrupted proton gradient and other downstream effects. Taken together these results provide strong evidence that SYP-14288 has a similar mode of action to the oxidative phosphorylation uncoupler Fluazinam but further investigation, including molecular studies, is required to completely characterize the SYP-14288 mode of action in P. capsici . However, the proteomic data collected in the current study does provide important insight into the overall effect of SYP-14288 in P. capsici , which could be useful for the registration and application of this novel fungicide." @default.
• W2971323430 created "2019-09-05" @default.
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• W2971323430 date "2019-08-27" @default.
• W2971323430 modified "2023-10-06" @default.
• W2971323430 title "Insights from the proteome profile of <i>Phytophthora capsici</i> in response to the novel fungicide SYP-14288" @default.
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• W2971323430 doi "https://doi.org/10.7717/peerj.7626" @default.
• W2971323430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6716503" @default.
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