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• W2971323772 abstract "Long-term outcomes of patients with branch-duct intraductal papillary mucinous neoplasms (IPMNs), particularly those after 5 years of surveillance, have not been fully evaluated in large studies. We analyzed incidences of IPMN-derived carcinoma and concomitant ductal adenocarcinoma (pancreatic ductal adenocarcinoma [PDAC]) over 20 years in a large population of patients.We identified 1404 consecutive patients (52% women; mean age, 67.5 years) with a diagnosis of branch-duct IPMN, from 1994 through 2017, at the University of Tokyo in Japan. Using a competing risk analysis, we estimated cumulative incidence of pancreatic carcinoma, overall and by carcinoma type. We used competing risks proportional hazards models to estimate subdistribution hazard ratios (SHRs) for incidences of carcinomas. To differentiate IPMN-derived and concomitant carcinomas, we collected genomic DNA from available paired samples of IPMNs and carcinomas and detected mutations in GNAS and KRAS by polymerase chain reaction and pyrosequencing.During 9231 person-years of follow-up, we identified 68 patients with pancreatic carcinomas (38 patients with IPMN-derived carcinomas and 30 patients with concomitant PDACs); the overall incidence rates were 3.3%, 6.6%, and 15.0% at 5, 10, and 15 years, respectively. Among 804 patients followed more than 5 years, overall cumulative incidence rates of pancreatic carcinoma were 3.5% at 10 years and 12.0% at 15 years from the initial diagnosis. The size of the IPMN and the diameter of the main pancreatic duct associated with incidence of IPMN-derived carcinoma (SHR 1.85; 95% confidence interval 1.38-2.48 for a 10-mm increase in the IPMN size and SHR 1.56; 95% confidence interval 1.33-1.83 for a 1-mm increase in the main pancreatic duct diameter) but not with incidence of concomitant PDAC.In a large long-term study of patients with branch-duct IPMNs, we found the 5-year incidence rate of pancreatic malignancy to be 3.3%, reaching 15.0% at 15 years after IPMN diagnosis. We observed heterogeneous risk factor profiles between IPMN-derived and concomitant carcinomas." @default.
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• W2971323772 date "2020-01-01" @default.
• W2971323772 modified "2023-10-15" @default.
• W2971323772 title "Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms" @default.
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• W2971323772 cites W1975940378 @default.
• W2971323772 cites W1990525751 @default.
• W2971323772 cites W2003917374 @default.
• W2971323772 cites W2016448153 @default.
• W2971323772 cites W2038981426 @default.
• W2971323772 cites W2040610108 @default.
• W2971323772 cites W2044023070 @default.
• W2971323772 cites W2051334830 @default.
• W2971323772 cites W2054990133 @default.
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• W2971323772 cites W2083979289 @default.
• W2971323772 cites W2090755771 @default.
• W2971323772 cites W2091415498 @default.
• W2971323772 cites W2093450947 @default.
• W2971323772 cites W2095885030 @default.
• W2971323772 cites W2100014692 @default.
• W2971323772 cites W2128198169 @default.
• W2971323772 cites W2131537357 @default.
• W2971323772 cites W2144173184 @default.
• W2971323772 cites W2148560417 @default.
• W2971323772 cites W2157716241 @default.
• W2971323772 cites W2182423514 @default.
• W2971323772 cites W2183695321 @default.
• W2971323772 cites W2285093314 @default.
• W2971323772 cites W2324090636 @default.
• W2971323772 cites W2346128824 @default.
• W2971323772 cites W2431396139 @default.
• W2971323772 cites W2601196685 @default.
• W2971323772 cites W2604454943 @default.
• W2971323772 cites W2617080203 @default.
• W2971323772 cites W2625769986 @default.
• W2971323772 cites W2736069212 @default.
• W2971323772 cites W2737129385 @default.
• W2971323772 cites W2741394533 @default.
• W2971323772 cites W2741518532 @default.
• W2971323772 cites W2748710555 @default.
• W2971323772 cites W2755014682 @default.
• W2971323772 cites W2759917145 @default.
• W2971323772 cites W2766526578 @default.
• W2971323772 cites W2792209856 @default.
• W2971323772 cites W2795199979 @default.
• W2971323772 cites W2798191310 @default.
• W2971323772 cites W2805154317 @default.
• W2971323772 cites W2884413168 @default.
• W2971323772 cites W2886810446 @default.
• W2971323772 cites W2887830846 @default.
• W2971323772 cites W2888288613 @default.
• W2971323772 cites W2895902053 @default.
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• W2971323772 cites W2915960039 @default.
• W2971323772 cites W3143617305 @default.
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• W2971323772 doi "https://doi.org/10.1053/j.gastro.2019.08.032" @default.
• W2971323772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31473224" @default.
• W2971323772 hasPublicationYear "2020" @default.
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