Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971329232> ?p ?o ?g. }
- W2971329232 endingPage "649" @default.
- W2971329232 startingPage "649" @default.
- W2971329232 abstract "Domestication has changed the natural evolutionary trajectory of horses by favoring the reproduction of a limited number of animals showing traits of interest. Reduced breeding stocks hampered the elimination of deleterious variants by means of negative selection, ultimately inflating mutational loads. However, ancient genomics revealed that mutational loads remained steady during most of the domestication history until a sudden burst took place some 250 years ago. To identify the factors underlying this trajectory, we gather an extensive dataset consisting of 175 modern and 153 ancient genomes previously published, and carry out the most comprehensive characterization of deleterious mutations in horses. We confirm that deleterious variants segregated at low frequencies during the last 3500 years, and only spread and incremented their occurrence in the homozygous state during modern times, owing to inbreeding. This independently happened in multiple breeds, following both the development of closed studs and purebred lines, and the deprecation of horsepower in the 20th century, which brought many draft breeds close to extinction. Our work illustrates the paradoxical effect of some conservation and improvement programs, which reduced the overall genomic fitness and viability." @default.
- W2971329232 created "2019-09-05" @default.
- W2971329232 creator A5030402857 @default.
- W2971329232 creator A5032664670 @default.
- W2971329232 date "2019-08-28" @default.
- W2971329232 modified "2023-10-15" @default.
- W2971329232 title "Origin and Evolution of Deleterious Mutations in Horses" @default.
- W2971329232 cites W1772281102 @default.
- W2971329232 cites W1918211613 @default.
- W2971329232 cites W1969095904 @default.
- W2971329232 cites W1990044652 @default.
- W2971329232 cites W1996342673 @default.
- W2971329232 cites W2002850151 @default.
- W2971329232 cites W2006712471 @default.
- W2971329232 cites W2010878576 @default.
- W2971329232 cites W2013093734 @default.
- W2971329232 cites W2016017635 @default.
- W2971329232 cites W2016261345 @default.
- W2971329232 cites W2032367243 @default.
- W2971329232 cites W2032457672 @default.
- W2971329232 cites W2033123297 @default.
- W2971329232 cites W2033290951 @default.
- W2971329232 cites W2055875124 @default.
- W2971329232 cites W2065035179 @default.
- W2971329232 cites W2070720545 @default.
- W2971329232 cites W2075777276 @default.
- W2971329232 cites W2077663320 @default.
- W2971329232 cites W2078065221 @default.
- W2971329232 cites W2091300200 @default.
- W2971329232 cites W2098705911 @default.
- W2971329232 cites W2121729179 @default.
- W2971329232 cites W2124031503 @default.
- W2971329232 cites W2129034036 @default.
- W2971329232 cites W2131732030 @default.
- W2971329232 cites W2140107142 @default.
- W2971329232 cites W2141320376 @default.
- W2971329232 cites W2144466056 @default.
- W2971329232 cites W2155800961 @default.
- W2971329232 cites W2161633633 @default.
- W2971329232 cites W2161973008 @default.
- W2971329232 cites W2167852161 @default.
- W2971329232 cites W2174026811 @default.
- W2971329232 cites W2219486408 @default.
- W2971329232 cites W2339048852 @default.
- W2971329232 cites W2520855549 @default.
- W2971329232 cites W2530141774 @default.
- W2971329232 cites W2531059752 @default.
- W2971329232 cites W2608850084 @default.
- W2971329232 cites W2759463260 @default.
- W2971329232 cites W2788733497 @default.
- W2971329232 cites W2800853838 @default.
- W2971329232 cites W2883041678 @default.
- W2971329232 cites W2887981236 @default.
- W2971329232 cites W2937139830 @default.
- W2971329232 cites W2939696785 @default.
- W2971329232 cites W2943362524 @default.
- W2971329232 cites W2949142043 @default.
- W2971329232 cites W2952255385 @default.
- W2971329232 cites W2955724900 @default.
- W2971329232 doi "https://doi.org/10.3390/genes10090649" @default.
- W2971329232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6769756" @default.
- W2971329232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31466279" @default.
- W2971329232 hasPublicationYear "2019" @default.
- W2971329232 type Work @default.
- W2971329232 sameAs 2971329232 @default.
- W2971329232 citedByCount "29" @default.
- W2971329232 countsByYear W29713292322019 @default.
- W2971329232 countsByYear W29713292322020 @default.
- W2971329232 countsByYear W29713292322021 @default.
- W2971329232 countsByYear W29713292322022 @default.
- W2971329232 countsByYear W29713292322023 @default.
- W2971329232 crossrefType "journal-article" @default.
- W2971329232 hasAuthorship W2971329232A5030402857 @default.
- W2971329232 hasAuthorship W2971329232A5032664670 @default.
- W2971329232 hasBestOaLocation W29713292321 @default.
- W2971329232 hasConcept C104317684 @default.
- W2971329232 hasConcept C134387633 @default.
- W2971329232 hasConcept C135763542 @default.
- W2971329232 hasConcept C144024400 @default.
- W2971329232 hasConcept C149923435 @default.
- W2971329232 hasConcept C153209595 @default.
- W2971329232 hasConcept C2776116246 @default.
- W2971329232 hasConcept C2777782036 @default.
- W2971329232 hasConcept C2908647359 @default.
- W2971329232 hasConcept C54355233 @default.
- W2971329232 hasConcept C78458016 @default.
- W2971329232 hasConcept C86803240 @default.
- W2971329232 hasConceptScore W2971329232C104317684 @default.
- W2971329232 hasConceptScore W2971329232C134387633 @default.
- W2971329232 hasConceptScore W2971329232C135763542 @default.
- W2971329232 hasConceptScore W2971329232C144024400 @default.
- W2971329232 hasConceptScore W2971329232C149923435 @default.
- W2971329232 hasConceptScore W2971329232C153209595 @default.
- W2971329232 hasConceptScore W2971329232C2776116246 @default.
- W2971329232 hasConceptScore W2971329232C2777782036 @default.
- W2971329232 hasConceptScore W2971329232C2908647359 @default.
- W2971329232 hasConceptScore W2971329232C54355233 @default.
- W2971329232 hasConceptScore W2971329232C78458016 @default.