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- W2971337283 abstract "Microglia are specialized brain macrophages that play numerous roles in tissue homeostasis and response to injury. Colony stimulating factor 1 receptor (CSF1R) is a receptor tyrosine kinase required for the development, maintenance, and proliferation of microglia. Here we show that in adult mice peripheral dosing of function-blocking antibodies to the two known ligands of CSF1R, CSF1, and IL-34, can deplete microglia differentially in white and gray matter regions of the brain, respectively. The regional patterns of depletion correspond to the differential expression of CSF1 and IL-34. In addition, we show that while CSF1 is required to establish microglia in the developing embryo, both CSF1 and IL-34 are required beginning in early postnatal development. These results not only clarify the roles of CSF1 and IL-34 in microglia maintenance, but also suggest that signaling through these two ligands might support distinct sub-populations of microglia, an insight that may impact drug development for neurodegenerative and other diseases." @default.
- W2971337283 created "2019-09-05" @default.
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- W2971337283 date "2019-09-20" @default.
- W2971337283 modified "2023-10-16" @default.
- W2971337283 title "CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions" @default.
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- W2971337283 doi "https://doi.org/10.3389/fimmu.2019.02199" @default.
- W2971337283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6764286" @default.
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