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- W2971365746 abstract "It is well known that immunosuppressed status such as cancer is a risk factor for herpes zoster (HZ), but little is known about whether HZ affects cancer development. This study aimed to investigate the association between HZ and the subsequent cancer risk by organ site. We conducted a nationwide retrospective cohort study using the Korean National Health Insurance claims database. The study enrolled 1,568,818 patients: 784,409 diagnosed with HZ between 2010 and 2015 were included in the HZ cohort, and 784,409 matched controls without HZ were included in the non-HZ cohort, with 1:1 exact matching for age, sex, and index year. Hazard ratios (HRs) were calculated for the risks of cancers based on anatomical site according to the HZ status using the Cox proportional hazards regression models. During a mean follow-up period of 6.0 years, 22,235 and 22,316 patients in the HZ and non-HZ cohorts, respectively, developed cancer (incidence rate: 7.6 vs. 7.7 per 1000 person-years). After adjusting for age, sex, and comorbidities, the overall risk of cancers was slightly decreased in HZ patients than in non-HZ cohorts (hazard ratio [HR] 1.00, 95% confidence interval [CI] 0.98-1.02). In post hoc analyses on organ site, the HZ cohort had significantly increased risks of hematologic malignancies, including multiple myeloma (HR 1.63, 95% CI 1.37–1.95), leukemia (HR 1.20, 95% CI 1.03–1.39), and lymphoma (HR 1.15, 95% CI 1.02–1.30) compared with the non-HZ cohort. Conversely, the risks of cancers in the liver (HR 0.87, 95% CI 0.82–0.93) and larynx (HR 0.73, 95% CI 0.58–0.92) were significantly decreased in HZ cohort compared with the non-HZ cohort. In conclusion, HZ patients showed a significant increase in hematologic malignancies, however the overall incidence of cancer is not higher than of controls without HZ." @default.
- W2971365746 created "2019-09-12" @default.
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- W2971365746 date "2019-09-01" @default.
- W2971365746 modified "2023-10-17" @default.
- W2971365746 title "123 Herpes Zoster and Risk of Cancer: A Nationwide Population-Based Cohort Study" @default.
- W2971365746 doi "https://doi.org/10.1016/j.jid.2019.07.127" @default.
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