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- W2971373125 endingPage "110572" @default.
- W2971373125 startingPage "110572" @default.
- W2971373125 abstract "Overexpression of the transcription factor, E2F8, has been associated with ovarian cancer. Objectives of this study were to determine: 1) if E2F8 gene expression in granulosa cells (GC) and theca cells (TC) change with follicular development, and 2) if E2F8 mRNA abundance in TC and GC is hormonally regulated. Using real-time PCR, E2F8 mRNA abundance in GC and TC was greater (P < 0.05) in small than large follicles. FGF9 induced an increase (P < 0.05) in E2F8 mRNA abundance by 1.6- to 7-fold in large-follicle (8–20 mm) TC and GC as well as in small-follicle (1–5 mm) GC. Abundance of E2F8 mRNA in TC was increased (P < 0.05) with FGF2, FGF9 or VEGFA treatments alone in vitro, and concomitant treatment of VEGFA with FGF9 increased (P < 0.05) abundance of E2F8 mRNA above any of the singular treatments; BMP4, WNT3A and LH were without effect. IGF1 amplified the stimulatory effect of FGF9 on E2F8 mRNA abundance by 2.7-fold. Collectively, our studies show for the first time that follicular E2F8 is developmentally and hormonally regulated indicating that E2F8 may be involved in follicular development." @default.
- W2971373125 created "2019-09-12" @default.
- W2971373125 creator A5001095520 @default.
- W2971373125 creator A5015513922 @default.
- W2971373125 creator A5062150911 @default.
- W2971373125 creator A5069018604 @default.
- W2971373125 creator A5070161872 @default.
- W2971373125 creator A5072575845 @default.
- W2971373125 date "2019-12-01" @default.
- W2971373125 modified "2023-10-17" @default.
- W2971373125 title "Regulation of the transcription factor E2F8 gene expression in bovine ovarian cells" @default.
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