FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971376329> ?p ?o ?g. }

• W2971376329 abstract "Exposure to insoluble particles in the lung elicits inflammatory responses that eliminate deposited particulates and repair damaged tissue. Overzealous or prolonged responses lead to chronic conditions, such as fibrosis and malignancy, which are frequently progressive and refractory to drug therapy leading to high rates of disability and mortality. The molecular events underlying the progression of lung inflammation to chronic pathology, in particular, the conversion to fibrosis, remain poorly understood. Fibrogenic multi-walled carbon nanotubes (MWCNTs) have been shown to stimulate prominent acute inflammation that evolves into chronic lesions characterized by chronic inflammation, interstitial fibrosis, and granulomas in mouse lungs. In this communication, we examined the in vivo activation of nuclear factor-κB (NF-κB) signaling in fibroblastic cells during the inflammatory and fibrotic progression induced by MWCNTs. Wild-type C57BL/6J male mice were exposed to two fibrogenic MWCNTs (Mitsui XNRI MWNT-7 and long MWCNTs) by pharyngeal aspiration. Both MWCNTs strongly stimulated the nuclear translocation of NF-κB p65 in lung fibroblasts and myofibroblasts during the acute and chronic responses. Phosphorylated NF-κB p65 at serine 276, a marker of NF-κB activation, was markedly induced by MWCNTs in the nucleus of fibroblastic cells. Moreover, two NF-κB-regulated genes encoding pro-fibrotic mediators, tissue inhibitor of metalloproteinase 1 (TIMP1), and osteopontin (OPN), respectively, were significantly induced in lung fibroblasts and myofibroblasts. These results demonstrate that NF-κB is activated to mediate transactivation of pro-fibrotic genes in fibroblastic cells during pulmonary acute and chronic responses to CNTs, providing a mechanistic framework for analyzing gene regulation in pulmonary fibrotic progression through NF-κB signaling." @default.
• W2971376329 created "2019-09-12" @default.
• W2971376329 creator A5018053837 @default.
• W2971376329 creator A5063863355 @default.
• W2971376329 date "2019-10-02" @default.
• W2971376329 modified "2023-10-01" @default.
• W2971376329 title "In Vivo Activation and Pro-Fibrotic Function of NF-κB in Fibroblastic Cells During Pulmonary Inflammation and Fibrosis Induced by Carbon Nanotubes" @default.
• W2971376329 cites W1533021978 @default.
• W2971376329 cites W1535444616 @default.
• W2971376329 cites W1581923494 @default.
• W2971376329 cites W1597764581 @default.
• W2971376329 cites W1615542914 @default.
• W2971376329 cites W1965024079 @default.
• W2971376329 cites W1965902122 @default.
• W2971376329 cites W1976382352 @default.
• W2971376329 cites W1985118687 @default.
• W2971376329 cites W1990974592 @default.
• W2971376329 cites W1995297665 @default.
• W2971376329 cites W1996771278 @default.
• W2971376329 cites W1999064578 @default.
• W2971376329 cites W2006791781 @default.
• W2971376329 cites W2019066164 @default.
• W2971376329 cites W2029445495 @default.
• W2971376329 cites W2034343019 @default.
• W2971376329 cites W2035351900 @default.
• W2971376329 cites W2036010329 @default.
• W2971376329 cites W2042073539 @default.
• W2971376329 cites W2042267093 @default.
• W2971376329 cites W2046315474 @default.
• W2971376329 cites W2056309150 @default.
• W2971376329 cites W2059277683 @default.
• W2971376329 cites W2064779937 @default.
• W2971376329 cites W2068137505 @default.
• W2971376329 cites W2069608579 @default.
• W2971376329 cites W2071052983 @default.
• W2971376329 cites W2085339674 @default.
• W2971376329 cites W2090327604 @default.
• W2971376329 cites W2094696148 @default.
• W2971376329 cites W2096021660 @default.
• W2971376329 cites W2124133814 @default.
• W2971376329 cites W2135919238 @default.
• W2971376329 cites W2137792105 @default.
• W2971376329 cites W2147239803 @default.
• W2971376329 cites W2148234755 @default.
• W2971376329 cites W2175478450 @default.
• W2971376329 cites W2275623113 @default.
• W2971376329 cites W2288337015 @default.
• W2971376329 cites W2292437567 @default.
• W2971376329 cites W2302524766 @default.
• W2971376329 cites W2464924799 @default.
• W2971376329 cites W2547353025 @default.
• W2971376329 cites W2556288254 @default.
• W2971376329 cites W2568018505 @default.
• W2971376329 cites W2621428836 @default.
• W2971376329 cites W2762451325 @default.
• W2971376329 cites W2801634291 @default.
• W2971376329 cites W2999065750 @default.
• W2971376329 cites W4379365691 @default.
• W2971376329 doi "https://doi.org/10.3389/fphar.2019.01140" @default.
• W2971376329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6783511" @default.
• W2971376329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31632276" @default.
• W2971376329 hasPublicationYear "2019" @default.
• W2971376329 type Work @default.
• W2971376329 sameAs 2971376329 @default.
• W2971376329 citedByCount "29" @default.
• W2971376329 countsByYear W29713763292020 @default.
• W2971376329 countsByYear W29713763292021 @default.
• W2971376329 countsByYear W29713763292022 @default.
• W2971376329 countsByYear W29713763292023 @default.
• W2971376329 crossrefType "journal-article" @default.
• W2971376329 hasAuthorship W2971376329A5018053837 @default.
• W2971376329 hasAuthorship W2971376329A5063863355 @default.
• W2971376329 hasBestOaLocation W29713763291 @default.
• W2971376329 hasConcept C104317684 @default.
• W2971376329 hasConcept C1292079 @default.
• W2971376329 hasConcept C142724271 @default.
• W2971376329 hasConcept C150903083 @default.
• W2971376329 hasConcept C164027704 @default.
• W2971376329 hasConcept C185592680 @default.
• W2971376329 hasConcept C203014093 @default.
• W2971376329 hasConcept C207001950 @default.
• W2971376329 hasConcept C207865475 @default.
• W2971376329 hasConcept C2776914184 @default.
• W2971376329 hasConcept C2780559512 @default.
• W2971376329 hasConcept C2780804394 @default.
• W2971376329 hasConcept C2781244666 @default.
• W2971376329 hasConcept C502942594 @default.
• W2971376329 hasConcept C55493867 @default.
• W2971376329 hasConcept C71924100 @default.
• W2971376329 hasConcept C86339819 @default.
• W2971376329 hasConcept C86803240 @default.
• W2971376329 hasConceptScore W2971376329C104317684 @default.
• W2971376329 hasConceptScore W2971376329C1292079 @default.
• W2971376329 hasConceptScore W2971376329C142724271 @default.
• W2971376329 hasConceptScore W2971376329C150903083 @default.
• W2971376329 hasConceptScore W2971376329C164027704 @default.
• W2971376329 hasConceptScore W2971376329C185592680 @default.
• W2971376329 hasConceptScore W2971376329C203014093 @default.
• W2971376329 hasConceptScore W2971376329C207001950 @default.
• W2971376329 hasConceptScore W2971376329C207865475 @default.

• next