Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971377345> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2971377345 endingPage "148" @default.
- W2971377345 startingPage "140" @default.
- W2971377345 abstract "Red blood cell exchange (RBCE) is the standard of care for patients with sickle cell disease (SCD) who present with severe vaso-occlusive crisis (VOC). However, subsets of these critically ill patients have progressive multiorgan failure (MOF) despite RBCE therapy. The purpose of this case series is to describe the use of plasma exchange (PLEX) for the treatment of SCD-related MOF that is refractory to RBCE.A retrospective case review of patients with severe MOF from sickle cell crisis unresponsive to RBCE who underwent PLEX in a 14-bed adult medical intensive care unit (ICU) at a tertiary care university hospital over a 4-year time period. Key laboratory data including complete blood count, indices of hemolysis, and markers of organ failure were recorded before and after both RBCE and PLEX.Our primary objective is to evaluate the effectiveness of PLEX, in addition to RBCE, on organ dysfunction, laboratory indices, and mortality. Of the 7 patients, 6 survived. Of the patients who survived, all remained hemodynamically stable during PLEX sessions and showed both clinical and laboratory evidences of improvement in hemolysis and organ function. Average time from completion of first PLEX treatment to initial laboratory signs of organ failure reversal for patients who survived was 15.6 hours, the average length of stay in the ICU was 5.6 days, and the average total length of stay in the hospital was 14 days.Plasma exchange, in addition to RBCE, may be a novel synergistic treatment option to decrease risk of mortality in patients with refractory VOC and MOF." @default.
- W2971377345 created "2019-09-12" @default.
- W2971377345 creator A5000707762 @default.
- W2971377345 creator A5013442715 @default.
- W2971377345 creator A5016280380 @default.
- W2971377345 creator A5050985788 @default.
- W2971377345 creator A5062379618 @default.
- W2971377345 date "2019-09-02" @default.
- W2971377345 modified "2023-10-16" @default.
- W2971377345 title "Reversal of Severe Multiorgan Failure Associated With Sickle Cell Crisis Using Plasma Exchange: A Case Series" @default.
- W2971377345 cites W1535567348 @default.
- W2971377345 cites W1809497812 @default.
- W2971377345 cites W1975561845 @default.
- W2971377345 cites W2019381418 @default.
- W2971377345 cites W2026606578 @default.
- W2971377345 cites W2037917295 @default.
- W2971377345 cites W2073626997 @default.
- W2971377345 cites W2093700724 @default.
- W2971377345 cites W2094155207 @default.
- W2971377345 cites W2095027102 @default.
- W2971377345 cites W2100360129 @default.
- W2971377345 cites W2104724413 @default.
- W2971377345 cites W2122472501 @default.
- W2971377345 cites W2136049237 @default.
- W2971377345 cites W2326476344 @default.
- W2971377345 cites W2405628819 @default.
- W2971377345 cites W2592339311 @default.
- W2971377345 cites W2738922327 @default.
- W2971377345 cites W2770305974 @default.
- W2971377345 cites W4293765499 @default.
- W2971377345 doi "https://doi.org/10.1177/0885066619874041" @default.
- W2971377345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31476954" @default.
- W2971377345 hasPublicationYear "2019" @default.
- W2971377345 type Work @default.
- W2971377345 sameAs 2971377345 @default.
- W2971377345 citedByCount "9" @default.
- W2971377345 countsByYear W29713773452021 @default.
- W2971377345 countsByYear W29713773452022 @default.
- W2971377345 countsByYear W29713773452023 @default.
- W2971377345 crossrefType "journal-article" @default.
- W2971377345 hasAuthorship W2971377345A5000707762 @default.
- W2971377345 hasAuthorship W2971377345A5013442715 @default.
- W2971377345 hasAuthorship W2971377345A5016280380 @default.
- W2971377345 hasAuthorship W2971377345A5050985788 @default.
- W2971377345 hasAuthorship W2971377345A5062379618 @default.
- W2971377345 hasConcept C121332964 @default.
- W2971377345 hasConcept C126322002 @default.
- W2971377345 hasConcept C142424586 @default.
- W2971377345 hasConcept C167135981 @default.
- W2971377345 hasConcept C2776376669 @default.
- W2971377345 hasConcept C2778384902 @default.
- W2971377345 hasConcept C2778426790 @default.
- W2971377345 hasConcept C2779902561 @default.
- W2971377345 hasConcept C2911084887 @default.
- W2971377345 hasConcept C2991859549 @default.
- W2971377345 hasConcept C71924100 @default.
- W2971377345 hasConcept C87355193 @default.
- W2971377345 hasConceptScore W2971377345C121332964 @default.
- W2971377345 hasConceptScore W2971377345C126322002 @default.
- W2971377345 hasConceptScore W2971377345C142424586 @default.
- W2971377345 hasConceptScore W2971377345C167135981 @default.
- W2971377345 hasConceptScore W2971377345C2776376669 @default.
- W2971377345 hasConceptScore W2971377345C2778384902 @default.
- W2971377345 hasConceptScore W2971377345C2778426790 @default.
- W2971377345 hasConceptScore W2971377345C2779902561 @default.
- W2971377345 hasConceptScore W2971377345C2911084887 @default.
- W2971377345 hasConceptScore W2971377345C2991859549 @default.
- W2971377345 hasConceptScore W2971377345C71924100 @default.
- W2971377345 hasConceptScore W2971377345C87355193 @default.
- W2971377345 hasIssue "2" @default.
- W2971377345 hasLocation W29713773451 @default.
- W2971377345 hasLocation W29713773452 @default.
- W2971377345 hasOpenAccess W2971377345 @default.
- W2971377345 hasPrimaryLocation W29713773451 @default.
- W2971377345 hasRelatedWork W1587616573 @default.
- W2971377345 hasRelatedWork W2118929970 @default.
- W2971377345 hasRelatedWork W2527740863 @default.
- W2971377345 hasRelatedWork W2794739697 @default.
- W2971377345 hasRelatedWork W2996014674 @default.
- W2971377345 hasRelatedWork W3127163951 @default.
- W2971377345 hasRelatedWork W3169783139 @default.
- W2971377345 hasRelatedWork W3217377045 @default.
- W2971377345 hasRelatedWork W4240782980 @default.
- W2971377345 hasRelatedWork W4299686961 @default.
- W2971377345 hasVolume "35" @default.
- W2971377345 isParatext "false" @default.
- W2971377345 isRetracted "false" @default.
- W2971377345 magId "2971377345" @default.
- W2971377345 workType "article" @default.